Cortical network functional connectivity in the descent to sleep
Cortical network functional connectivity in the descent to sleep
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DOI：
10.1073/pnas.0900924106
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发表时间：
2009-03-17
影响因子：
11.1
通讯作者：
Raichle, Marcus E.
中科院分区：
文献类型：
--
作者：
Larson-Prior, Linda J.;Zempel, John M.;Raichle, Marcus E.
进入睡眠伴随着有意识的大脑与外部世界的分离。因此，这个过程应该与已知介导与环境相互作用的大脑区域的神经活动减少有关。我们研究了血氧依赖（BOLD）信号的功能连接使用传统的种子为基础的分析在3个主要的感觉和3个协会网络作为正常的年轻人从清醒过渡到浅睡眠，而躺在不动的孔的磁共振成像扫描仪。在所有被检查的唤醒状态中，每个网络都保持着功能连接。事实上，与清醒状态相比，在轻度睡眠期间，背侧注意力网络内的相关性适度但显着增加。此外，我们的数据表明，神经元介导的BOLD信号的变化一般增加轻睡眠。这些结果并不支持持续的BOLD波动主要反映无约束认知的观点。相反，越来越多的证据支持这一假设，即自发BOLD波动反映了维持大脑功能系统完整性的过程。
Descent into sleep is accompanied by disengagement of the conscious brain from the external world. It follows that this process should be associated with reduced neural activity in regions of the brain known to mediate interaction with the environment. We examined blood oxygen dependent ( BOLD) signal functional connectivity using conventional seed-based analyses in 3 primary sensory and 3 association networks as normal young adults transitioned from wakefulness to light sleep while lying immobile in the bore of a magnetic resonance imaging scanner. Functional connectivity was maintained in each network throughout all examined states of arousal. Indeed, correlations within the dorsal attention network modestly but significantly increased during light sleep compared to wakefulness. Moreover, our data suggest that neuronally mediated BOLD signal variance generally increases in light sleep. These results do not support the view that ongoing BOLD fluctuations primarily reflect unconstrained cognition. Rather, accumulating evidence supports the hypothesis that spontaneous BOLD fluctuations reflect processes that maintain the integrity of functional systems in the brain.