Enterostatin (VPDPR) Has Anti-analgesic and Anti-amnesic Activites
Enterostatin (VPDPR) Has Anti-analgesic and Anti-amnesic Activites
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肠抑素 (VPDPR) 具有抗镇痛和抗遗忘活性
DOI：
10.1271/bbb.65.236
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
M. Yoshikawa
中科院分区：
文献类型：
--
作者：
Y. Takenaka;F. Nakamura;Y. Jinsmaa;A. Lipkowski;M. Yoshikawa
肠抑素(VPDPR)是一种来源于前脂酶氨基末端的厌食肽，可显著抑制μ阿片激动剂吗啡(5 mg/kg，S.C.)的镇痛作用。在I.C.V.之后。给小鼠灌胃100nmoL。另一方面，VPDPR(∼200nmol，i.c.v.)不减弱κ阿片激动剂D-Phe-D-Phe-D-Nle-D-Arg-NH_2(100μg/只，i.c.v)的镇痛作用。或δ阿片激动剂DTLET(4nmoL/只小鼠，i.c.v)。VPDPR(100nmol，i.c.V.)能显著改善东莨菪碱(0.2 mg/kg，i.p)所致的记忆障碍。在老鼠身上。然而，相同剂量的VPDPR并不能增强正常小鼠的记忆。
Enterostatin (VPDPR), an anorexigenic peptide derived from the amino terminus of procolipase, significantly inhibited analgesia induced by the μ-opioidagonist morphine (5 mg/kg, s.c.) after i.c.v. administration to mice at a dose of 100 nmol. On the other hand, VPDPR (∼200 nmol, i.c.v.) did not attenuate analgesia induced by the κ-opioid agonist D-Phe-D-Phe-D-Nle-D-Arg-NH2 (100 μg/mouse, i.c.v.) or δ-opioid agonist DTLET (4 nmol/mouse, i.c.v.). VPDPR (100 nmol, i.c.v.) significantly improved amnesia induced by scopolamine (0.2 mg/kg, i.p.) in mice. However, VPDPR did not enhance memory in normal mice at the same dose.