Neural substrates linking balance control and anxiety
Neural substrates linking balance control and anxiety
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DOI：
10.1016/s0031-9384(02)00935-6
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发表时间：
2002-12-01
影响因子：
2.9
通讯作者：
Balaban, CD
中科院分区：
文献类型：
--
作者：
Balaban, CD
这一交流提供了我们对平衡控制和焦虑之间密切联系的神经学基础的最新理解。新的数据表明，前庭受体区域的臂旁核（PBN）包含细胞响应身体旋转和位置相对于重力。PBN与扩展的中央杏仁核、下边缘皮层和下丘脑的相互关系，似乎是处理会聚前庭、躯体和内脏信息处理以介导回避条件反射、焦虑和条理性恐惧反应的初级网络中的重要节点。去甲肾上腺素能和血清素能投射到前庭核也与焦虑通路有平行联系。蓝斑-前庭通路起源于尾侧蓝斑（LC），并向前庭核提供区域专门化的去肾上腺素能输入，这可能介导了前庭-运动回路的报警和警戒作用。来自中缝背核和中缝暗核的5-羟色胺能和非5-羟色胺能通路也以不同的方式投射到前庭核，5-HT2A受体在PBN的杏仁核和皮层靶点表达。有人提出，中缝背核通路有助于(a)对自我运动的反应的运动和感觉（信息收集）方面的权衡，以及(b)对运动的厌恶方面的情感反应的敏感性的校准。这一更新的神经学模型继续成为研究平衡障碍和焦虑障碍共病的神经学和神经化学基础的综合模式。(C) 2002爱思唯尔科学有限公司版权所有。
This communication provides an update of our understanding of the neurological bases for the close association between balance control and anxiety. New data suggest that a vestibulo-recipient region of the parabrachial nucleus (PBN) contains cells that respond to body rotation and position relative to gravity. The PBN, with its reciprocal relationships with the extended central amygdaloid nucleus, infiralimbic cortex, and hypothalamus, appears to be an important node in a primary network that processes convergent vestibular, somatic, and visceral information processing to mediate avoidance conditioning, anxiety, and conditioned fear responses. Noradrenergic and serotonergic projections to the vestibular nuclei also have parallel connections with anxiety pathways. The coeruleo-vestibular pathway originates in caudal locus coeruleus (LC) and provides regionally specialized noradrenergic input to the vestibular nuclei, which likely mediate effects of alerting and vigilance on the sensitivity of vestibulo-motor circuits. Both serotonergic and nonserotonergic pathways from the dorsal raphe nucleus and the nucleus raphe obscurus also project differentially to the vestibular nuclei, and 5-HT2A receptors are expressed in amygdaloid and cortical targets of the PBN. It is proposed that the dorsal raphe nucleus pathway contributes to both (a) a tradeoff between motor and sensory (information gathering) aspects of responses to self-motion and (b) a calibration of the sensitivity of affective responses to aversive aspects of motion. This updated neurologic model continues to be a synthetic schema for investigating the neurological and neurochemical bases for comorbidity of balance disorders and anxiety disorders. (C) 2002 Elsevier Science Inc. All rights reserved.