Mission and Sustainability of Informatics for Integrating Biology and the Bedside (i2b2).
Mission and Sustainability of Informatics for Integrating Biology and the Bedside (i2b2).
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DOI：
10.13063/2327-9214.1074
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Wilcox A
中科院分区：
文献类型：
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作者：
Murphy S;Wilcox A
医疗保健领域成功传播的研究项目的一个明显例子是整合生物学和床边信息学（Informatics for Integrating Biology and the Bedside）（i2b2）。该项目提供的软件可以让研究人员对医院的电子医疗数据进行直接的自助查询。这些查询的目标是找到符合特定情况的患者群体，同时提供患者隐私和自由裁量权。维持这一资源并保持其方向一直是一个挑战，但随着为期十年的国家生物医学计算中心 (NCBC) 停止资助，这一挑战变得更加严峻。以 i2b2 结构为基础，有助于利用它的赠款传播计划，因为它是一种传播的国家资源。虽然这并没有直接增加 i2b2 内部的支持，但它提高了机构利用资源的能力，通常会导致机构支持的增加。 i2b2 的成功开发、使用和传播对于临床研究和信息学具有重要意义。它的演变已经从本地研究数据基础设施发展成为比国家生物医学计算中心的任何其他产品传播更广泛的基础设施，并且基础设施产生的投资比最初用于创建它的投资还要大。在整个过程中，关于传播的好处有两个主要教训：人们在以不同方式利用资源方面具有巨大的创造力，并且更广泛的系统使用可以使系统更加强大。中央机构长期可持续性的一个选择是将这一职能转移给行业合作伙伴。目前正在寻求的另一个选择是创建一个基金会，作为该项目的中央机构。在过去的 10 年里，i2b2 已成为医疗保健研究人员工具包中的重要组成部分。现在有超过 110 家医院使用 i2b2 进行研究。这个开源平台拥有一个开发人员社区，他们不断增强平台的分析能力并发明新功能。通过了解 i2b2 如何持续下去，我们希望其他研究基础设施项目可以更好地引导选择，使这些举措随着时间的推移可持续发展。
A visible example of a successfully disseminated research project in the healthcare space is Informatics for Integrating Biology and the Bedside, or i2b2. The project serves to provide the software that can allow a researcher to do direct, self-serve queries against the electronic healthcare data form a hospital. The goals of these queries are to find cohorts of patients that fit specific profiles, while providing for patient privacy and discretion. Sustaining this resource and keeping its direction has always been a challenge, but ever more so as the ten year National Centers for Biomedical Computing (NCBCs) sunset their funding. Building on the i2b2 structures has helped the dissemination plans for grants leveraging it because it is a disseminated national resource. While this has not directly increased the support of i2b2 internally, it has increased the ability of institutions to leverage the resource and generally leads to increased institutional support. The successful development, use, and dissemination i2b2 has been significant in clinical research and informatics. Its evolution has been from a local research data infrastructure to one disseminated more broadly than any other product of the National Centers for Biomedical Computing, and an infrastructure spawning larger investments than were originally used to create it. Throughout this, there were two main lessons about the benefits of dissemination: that people have great creativity in utilizing a resource in different ways and that broader system use can make the system more robust. One option for long-term sustainability of the central authority would be to translate the function to an industry partner. Another option currently being pursued is to create a foundation that would be a central authority for the project. Over the past 10 years, i2b2 has risen to be an important staple in the toolkit of health care researchers. There are now over 110 hospitals that use i2b2 for research. This open-source platform has a community of developers that are continuously enhancing the analytic capacities of the platform and inventing new functionality. By understanding how i2b2 has been sustained, we hope that other research infrastructure projects may better navigate options in making those initiatives sustainable over time.