Food hardness can regulate orthodontic tooth movement in mice.
Food hardness can regulate orthodontic tooth movement in mice.
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食物硬度可以调节小鼠正畸牙齿的移动。
DOI：
10.1111/jre.12945
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发表时间：
2022
影响因子：
3.5
通讯作者：
Ho,SunitaP
中科院分区：
文献类型：
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作者：
Ustriyana,Putu;He,Rui;Srirangapatanam,Sudarshan;Chang,Jasper;Arman,SheelerT;Sidhu,Sukhmandeep;Wang,Bo;Kang,Misun;Ho,SunitaP
背景和目的正畸治疗中经常伴随着给患者开具较软的食物处方。要问的问题是，这种规定的负荷方案符合沃尔夫定律，它是否提供了足够的机械刺激，以保持牙周复合体的功能健康？通过研究小鼠在经历实验性牙齿移动（ETM）时咀嚼软食物（SF）和硬食物（HF）的影响来回答这个问题。方法三周龄的C57 BL/6小鼠（n= 18）被喂食硬颗粒（HF;n= 9）或软食物（SF;n= 9）。对8周龄的小鼠进行ETM，并在1分钟、2周和4周（分别为8、10和12周龄）时对小鼠实施安乐死。Logistic回归模型应用于实验数据外推ETM的长期影响的物理特征的dentoalveolar joint（DAJ）.ResultsBy 12周，咀嚼SF的小鼠表示更广泛的牙周膜空间比那些咀嚼HF。咀嚼SF的小鼠表现出更大的肺泡和减少的骨体积分数，但具有显着降低的骨矿物质密度和减少的整体牙齿movement.ConclusionsThese改变的物理特征时，情境化的DAJ内说明，（a）该地区远离“侮辱的网站”也经历了显着的适应，和（B）这些适应性在牙周复合体的近中侧和远中侧之间变化，并且在ETM的方向上在形貌上不同。这些见解支持了主要结论，即需要在ETM后将“调节咀嚼负荷”作为治疗剂量，以促进牙周复合体的再生作为有效的临床结果。所讨论的多尺度图像分析也可以用于患者锥束计算机断层扫描数据，以确定口腔正畸治疗的咀嚼功能领域内的有效性。
Background and objectivesOrthodontic treatment is often accompanied with prescription of softer foods to patients. The question to ask is, is this prescribed load regimen congruent with Wolff's law, and does it provide an adequate mechanical stimulus to maintain the functional health of periodontal complex? This question was answered by studying the effects of mice chewing on soft food (SF) and hard food (HF) while undergoing experimental tooth movement (ETM).MethodsThree‐week‐old C57BL/6 mice (n= 18) were fed either hard pellet (HF;n= 9) or soft‐chow food (SF;n= 9). ETM was performed on mice at 8 weeks of age, and mice were euthanized at 1 min, 2 weeks, and 4 weeks (8, 10, and 12 weeks old, respectively). A logistic regression model was applied to the experimental data to extrapolate the prolonged effects of ETM on the physical features of the dentoalveolar joint (DAJ).ResultsBy 12 weeks, mice that chewed on SF expressed wider periodontal ligament space than those that chewed on HF. Mice that chewed on SF demonstrated increased alveolar socket roughness with larger alveoli and decreased bone volume fraction but with significantly lower bone mineral density and reduced overall tooth movement.ConclusionsThese altered physical features when contextualized within the DAJ illustrated that (a) the regions farther away from the “site of insult” also undergo significant adaptation, and (b) these adaptations vary between mesial and distal sides of the periodontal complex and topographically differentiate in the direction of the ETM. These insights underpin the main conclusion, in that there is a need to “regulate chewing loads” as a therapeutic dose following ETM to encourage regeneration of periodontal complex as an effective clinical outcome. The discussed multiscale image analyses also can be used on patient cone beam computed tomography data to identify the effectiveness of orthodontic treatment within the realm of masticatory function.