Weight loss and bone mineral density in obese adults: a longitudinal analysis of the influence of very low energy diets.
Weight loss and bone mineral density in obese adults: a longitudinal analysis of the influence of very low energy diets.
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DOI：
10.1186/s40842-018-0063-6
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发表时间：
2018-01-01
影响因子：
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通讯作者：
Peterson, Mark
中科院分区：
文献类型：
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作者：
Choksi, Palak;Rothberg, Amy;Peterson, Mark
背景：减肥对骨骼健康的长期影响还不清楚。本研究的目的是检查使用极低能量饮食（VLED）的强化医学减肥干预的影响（~ 800卡/天），导致体重显著变化，全身骨密度（BMD）超过2年。我们研究了VLED诱导的体重减轻对BMD和FFM的影响。49名受试者在3- 6个月后和2年后体重维持期间再次测量（无脂肪质量）。以基线BMD（或FFM）作为协变量，年龄、性别和体重变化作为主要模型预测因子，采用一般线性模型评估绝对和相对体重减轻率（以千克为单位的体重变化）的影响（体重：23.51±12.5kg）比女性（体重：16.8±19.2kg），女性的BMD损失更大（0.03±0.04g/cm 2 vs 0.01±0.04g/cm 2）（所有p
BACKGROUND: The long-term effect of weight reduction on skeletal health is not well understood. The purpose of this study was to examine the impact of an intensive medical weight loss intervention using very low energy diet (VLED) (~800cal/day) that result in significant changes in body weight, on total body bone mineral density (BMD) over 2years.METHODS: We examined the impact of VLED-induced weight loss on BMD and FFM (Fat-free Mass) after 3-6months and again while in weight maintenance at 2years in 49 subjects. The effects of absolute and relative rate of weight reduction assessed by change in weight in kilograms were assessed using general linear modeling, with baseline BMD (or FFM) as a covariate, and age, sex and changes in body weight as primary model predictors.RESULTS: At the end of 2years, the average weight loss was greater for men (weight: 23.51±12.5kg) than women (weight: 16.8±19.2kg) and BMD loss was greater among women (0.03±0.04g/cm2 vs 0.01±0.04g/cm2) (all p