Dendritic spread and functional coverage of Starburst amacrine cells
Dendritic spread and functional coverage of Starburst amacrine cells
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DOI：
10.1002/cne.21518
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发表时间：
2007-12-10
影响因子：
2.5
通讯作者：
Reese, Benjamin E.
中科院分区：
文献类型：
--
作者：
Keeley, Patrick W.;Whitney, Irene E.;Reese, Benjamin E.
星爆无长突细胞网络在视网膜内方向选择性的神经回路中发挥着重要作用。星爆树突场的各个部分凭借具有重叠树突的星爆无长突细胞之间的相互抑制关系而具有方向选择性。星爆无长突细胞网络的这些特征表明星爆细胞调节其树突重叠以确保视网膜表面的均匀覆盖。本研究比较了星爆无长突细胞数量不同的两种不同品系小鼠的星爆无长突细胞的树突形态。 A/J (A) 品系所含的星爆型无长突细胞比 C57BL/6J (B6) 品系少约四分之一，尽管两种品系中星爆型无长突细胞的镶嵌图案相似。然而，树突区域大小并不能补偿密度差异，A 菌株具有相对于 B6 菌株稍小的树突区域，从而为 B6 菌株中的单个细胞产生显着更大的树突覆盖因子。树突场远端（输出）环面的面积在两个菌株中占据了整个场面积的相当比例，但重叠的环面在 B6 菌株中建立了更精细的共束过程网格。这些结果表明，树突网络的结构，而不是树突区域的整体大小，取决于星爆无长突细胞的密度。 J.Comp。内罗尔。 505: 539-546, 2007。(c) 2007 Wiley-Liss, Inc.
The network of starburst amacrine cells plays a fundamental role in the neural circuitry underlying directional selectivity within the retina. Individual sectors of the starburst dendritic field are directionally selective by virtue of a mutually inhibitory relationship between starburst amacrine cells with overlapping dendrites. These features of the starburst amacrine cell network suggest that starburst cells regulate their dendritic overlap to ensure a uniform coverage of the retinal surface. The present study has compared the dendritic morphology of starburst amacrine cells in two different strains of mice that differ in starburst amacrine cell number. The A/J (A) strain contains about one-quarter fewer starburst amacrine cells than does the C57BL/6J (B6) strain, although the mosaics of starburst amacrine cells in both strains are comparably patterned. Dendritic field size, however, does not compensate for the difference in density, the A strain having a slightly smaller dendritic field relative to the B6 strain, yielding a significantly larger dendritic coverage factor for individual cells in the B6 strain. The area of the distal (output) annulus of the dendritic field occupies a comparable proportion of the overall field area in the two strains, but overlapping annuli establish a finer meshwork of co-fasciculating processes in the B6 strain. These results would suggest that the architecture of the dendritic network, rather than the overall size of the dendritic field, is dependent on the density of starburst amacrine cells. J. Comp. Neurol. 505: 539-546, 2007. (c) 2007 Wiley-Liss, Inc.