Bioadhesive polymer semiconductors and transistors for intimate biointerfaces
Bioadhesive polymer semiconductors and transistors for intimate biointerfaces
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DOI：
10.1126/science.adg8758
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发表时间：
2023-08-11
期刊：
影响因子：
56.9
通讯作者：
Wang, Sihong
中科院分区：
文献类型：
--
作者：
Li, Nan;Li, Yang;Wang, Sihong
生物电子设备的使用依赖于与软生物组织的直接接触。对于晶体管型生物电子器件，需要与生物组织直接连接以进行有效信号转导的半导体不能很好地与湿组织粘附，从而限制了界面处的稳定性和适形性。我们报告了一种生物粘附聚合物半导体，通过由生物粘附刷聚合物和氧化还原活性半导体聚合物形成的双网络结构。所得的半导体薄膜可以与湿组织表面形成快速而强的粘附力，并且具有大约每秒每伏特1平方厘米的高载流子迁移率、高拉伸性和良好的生物相容性。进一步制造完全生物粘附晶体管传感器使我们能够在离体大鼠心脏和体内大鼠肌肉上产生高质量且稳定的电生理记录。
The use of bioelectronic devices relies on direct contact with soft biotissues. For transistor-type bioelectronic devices, the semiconductors that need to have direct interfacing with biotissues for effective signal transduction do not adhere well with wet tissues, thereby limiting the stability and conformability at the interface. We report a bioadhesive polymer semiconductor through a double-network structure formed by a bioadhesive brush polymer and a redox-active semiconducting polymer. The resulting semiconducting film can form rapid and strong adhesion with wet tissue surfaces together with high charge-carrier mobility of similar to 1 square centimeter per volt per second, high stretchability, and good biocompatibility. Further fabrication of a fully bioadhesive transistor sensor enabled us to produce high-quality and stable electrophysiological recordings on an isolated rat heart and in vivo rat muscles.