Thalidomide in Rabbit Semen
Thalidomide in Rabbit Semen
复制标题
兔精液中的沙利度胺
作者：
C. Lutwak‐Mann;K. Schmid;H. Keberle
在早期的研究中发现，当雄性家兔在数周内摄入沙利度胺时，每只动物的整个实验剂量不超过2.5 g，它对随后的生殖性能产生不利影响（参考文献。1和2以及未发表的意见）。由10只雄性和90只雌性组成的实验表明，虽然一些接受治疗的雄性的繁殖能力受到的影响比其他雄性小得多，但长期摄入沙利度胺的总体不利影响在103只实验交配中的72只中表现如下：在18个怀孕失败，在12个出生的年轻人的数量是低的，在25个超过一半的窝失去了出生后14天，在11个年轻人出生时体重严重不足，6只幼仔畸形（脊柱裂、无尾、颅泡、双肾缺失、后肢瘫痪、无骨化中心、前肢对称性血管瘤）。要从正确的角度看待这些结果，必须将其与兔群中一贯的高妊娠率、优良的窝仔数和存活率以及小于1%的自发性总体畸形发生率相对照。
IT was found in an earlier study that when thalidomide is ingested by male rabbits over a period of weeks, the entire experimental dose not exceeding 2.5 g per animal, it exerts an unfavourable influence on their subsequent reproductive performance (refs. 1 and 2 and unpublished observations). Experiments comprising ten males and ninety females of proved high fertility indicated that while the breeding capacity in some of the treated males was much less seriously affected than in others, the overall untoward effect of prolonged intake of thalidomide expressed itself in seventy-two of 103 experimental matings as follows: in eighteen pregnancy failed to ensue, in twelve the number of young born was low, in twenty-five more than half the litter was lost by 14 days after birth, in eleven the young were grossly underweight at birth, and in six the young were malformed (spina bifida, absence of tail, cranial blister, absence of both kidneys, paralysis of hind limbs with lack of centres of ossification, and symmetrical haemangioma of the fore-limbs). To be seen in their proper light, these results must be set against the consistently high incidence of pregnancy in the rabbit colony, the excellent litter size and survival, and an incidence of spontaneous gross malformation of less than 1 per cent.