Bionanostructure-catalyzed one-pot three-component synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives under solvent-free conditions
Bionanostructure-catalyzed one-pot three-component synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives under solvent-free conditions
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DOI：
10.1016/j.reactfunctpolym.2016.10.013
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发表时间：
2016-12-01
影响因子：
5.1
通讯作者：
Paydar, Reza
中科院分区：
文献类型：
--
作者：
Maleki, Ali;Paydar, Reza
本工作合成了一种绿色生物纳米复合催化剂--壳聚糖/氧化石墨烯，并通过傅里叶变换红外光谱（FT-IR）、热重分析（TGA）、差示扫描量热分析（DSC）、原子力显微镜（AFM）和扫描电子显微镜（SEM）对其进行了表征。然后，将其作为纳米催化剂用于苯甲醛、1，3-酮酯和脲的一锅三组分缩合反应，在无溶剂条件下以优异的产率和较短的反应时间合成了3，4-二氢嘧啶-2（1H）-酮衍生物。反应后处理简单，催化剂易于从反应混合物中分离并重复使用。(C)2016爱思唯尔B. V.保留所有权利。
In this work, chitosan/graphene oxide as a green bionanocomposite catalyst was synthesized and characterized by Fourier transform infrared spectroscopy (FT-IR) spectra, thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC) analysis, atomic force microscopy (AFM) and scanning electron microscopy (SEM) images. Then, it was used as a nanocatalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives by a one-pot three-component condensation reaction of benzaldehyde, 1,3-ketoesters and urea in excellent yields and short reaction times under solvent-free conditions. The reaction work-up was simple and the catalyst could easily be separated from the reaction mixture and reused in subsequent reactions. (C) 2016 Elsevier B.V. All rights reserved.