New regulatory mechanisms for human extravillous trophoblast invasion.
New regulatory mechanisms for human extravillous trophoblast invasion.
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DOI：
10.1111/j.1447-0578.2005.00104.x
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发表时间：
2005-09-01
影响因子：
3.4
通讯作者：
Higuchi, Toshihiro
中科院分区：
文献类型：
--
作者：
Fujiwara, Hiroshi;Sato, Yukiyasu;Higuchi, Toshihiro
人类绒毛外滋养层细胞(EVT)在胎盘形成早期侵入母体蜕膜并重建母体螺旋动脉。然而，诱导EVT侵袭动脉和/或保护EVT免受进一步侵袭的确切调控机制还不是很清楚。最近发现，已经停止侵袭的EVT在其细胞表面特异性表达分化簇(CD9)和二肽基肽酶IV(DPPIV)。此外，迁移至母体螺旋动脉的EVT表达CC趋化因子受体-1(CCR-1)，它是一种趋化因子受体，调节激活正常T细胞表达和分泌(RANTES)等。CD9与细胞表面的整合素分子相关，被认为调节整合素的功能。相反，DPPIV是一种细胞表面多肽酶，在RANTES进入趋化因子受体之前，它可以在细胞外位置代谢RANTES。体外功能分析表明CD9、DPPIV和RANTES参与了EVT侵袭的调控。这些结果表明，CD9和DPPIV，包括趋化因子，可能是人绒毛外滋养层细胞的新的调节因子。(Reprod Med Biol 2005；4：189-195)。
Human extravillous trophoblasts (EVT) invade maternal deciduas and reconstructed maternal spiral arteries during early placentation. However, the precise regulatory mechanisms to induce EVT invasion toward arteries and/or to protect EVT from further invasion have not been well understood. Recently, it was found that EVT that had already ceased their invasion, specifically expressed cluster of differentiation (CD9) and dipeptidyl peptidaseIV (DPPIV) on their cell surface. In addition, EVT migrating to maternal spiral arteries expressed CC chemokine receptor type-1 (CCR-1), which is a chemokine receptor for regulated on activation normal T cell expressed and secreted (RANTES) and so on. CD9 is associated with integrin molecules on the cell surface and is considered to modulate integrin function. In contrast, DPPIV is a cell surface peptidase that can metabolize RANTES at extracellular sites before its accessing to the chemokine receptors. In vitro functional assay showed that CD9, DPPIV and RANTES are involved in the regulation for EVT invasion. From these findings, it can be proposed that CD9 and DPPIV, including chemokines, are new regulatory factors for human extravillous trophoblasts. (Reprod Med Biol 2005; 4: 189-195).