An effective method to produce 7-epitaxol from taxol in HCO 3?
An effective method to produce 7-epitaxol from taxol in HCO 3?
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一种在HCO 3 中由紫杉醇生产7-外紫杉醇的有效方法？
DOI：
10.1016/j.bmcl.2020.127285
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发表时间：
2020-08-01
影响因子：
2.7
通讯作者：
Zhu, Xudong
中科院分区：
文献类型：
--
作者：
Liu, Yanjie;Ma, Xiaoyu;Zhu, Xudong
已知7-表紫杉醇比紫杉醇具有更强的细胞毒性。然而，红豆杉中7-表紫杉醇的含量远低于紫杉醇，这使得它的获得成本更高。我们在这里描述了一种有效地将紫杉醇转化为7-表紫杉醇的方法。反应的关键条件是以NaHCO 3为溶剂，乙腈为溶剂。转化率可达82%以上。
It is known that 7-epitaxol has much stronger cytotoxicity than taxol does. However, the content of 7-epitaxol in yew is much less than taxol, which makes it more costly to obtain. We describe here a method to effectively convert taxol to 7-epitaxol. The key condition for reaction needs NaHCO3in solvent acetonitrile (ACN). The conversion rate can be over 82%.