Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells
Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells
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DOI：
10.1074/jbc.ra118.006378
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发表时间：
2019-03-15
影响因子：
4.8
通讯作者：
Broer, Stefan
中科院分区：
文献类型：
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作者：
Broer, Angelika;Gauthier-Coles, Gregory;Broer, Stefan
中性氨基酸转运体溶质载体家族成员5(SLC1A5或ASCT2)在许多肿瘤中过表达。为了确定它在肿瘤中的作用，我们使用了带有或不带有ASCT2缺失的143B骨肉瘤细胞和HCC1806三阴性乳腺癌细胞。ASCT2ko 143B细胞在标准培养基中生长良好，但ASCT2在
The neutral amino acid transporter solute carrier family 1 member 5 (SLC1A5 or ASCT2) is overexpressed in many cancers. To identify its roles in tumors, we employed 143B osteosarcoma cells and HCC1806 triple-negative breast cancer cells with or without ASCT2 deletion. ASCT2ko 143B cells grew well in standard culture media, but ASCT2 was required for optimal growth at