Longitudinal Study of Optic Cup Progression in Children
Longitudinal Study of Optic Cup Progression in Children
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DOI：
10.3928/01913913-20100719-06
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发表时间：
2011-05-01
影响因子：
1.2
通讯作者：
Demer, Joseph L.
中科院分区：
文献类型：
--
作者：
Park, Hee-Jung;Hampp, Christian;Demer, Joseph L.
目的：确定儿童杯盘比(C：D)进展的标准比率以及早产和低出生体重对这一比率的影响。方法：在一项单一的儿科眼科实践中，一名检查员通过连续眼底镜对92例(184眼)未接受眼内手术或未患视神经疾病的患者进行为期至少5年的视杯大小评估。对0~10岁儿童进行C：D横断面分析，并用线性回归方法比较早产儿与足月儿、低出生体重儿与正常出生体重儿的C：D进展。在足月儿童中，C：D平均每年增加0.0075。早产儿的平均C：D进展率是两倍：每年龄年0.0160(与足月相比，P=0.049)。当比较低出生体重和正常儿童时，也观察到类似的，不显著的趋势(P=.131)。结论：早产和低出生体重与儿童拔火罐的发生率增加有关。临床医生应该认识到，C：D进展并不是儿童青光眼的特殊征兆。
Purpose: To determine the normative rate of cup-to-disc-ratio (C: D) progression in children and the effect of prematurity and low birth weight on this rate.Method: In a single pediatric ophthalmology practice, a single examiner evaluated optic cup size by serial ophthalmoscopy over a minimum of 5 years in 92 patients (184 eyes) without intraocular surgery or optic nerve disease. A cross-sectional analysis of C: D was performed per year of age from 0 to 10 years and linear regression was used to compare C: D progression between preterm and term children and between low versus normal birth weight children.Results: Children exhibited progressive optic cup-ping. In term children, mean C: D increased by 0.0075 per year. Rate of mean C: D progression was double in children born preterm: 0.0160 (P=.049, comparison to term) per age-year. A similar, nonsignificant trend is observed when comparing low birth weight to normal children (P=.131).Conclusion: Prematurity and low birth weight are associated with increased rate of cupping in children. Clinicians should recognize that C: D progression is not a specific sign of glaucoma in children.