Intracranial pressure pulse morphological features improved detection of decreased cerebral blood flow.
Intracranial pressure pulse morphological features improved detection of decreased cerebral blood flow.
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DOI：
10.1088/0967-3334/31/5/006
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发表时间：
2010-05
影响因子：
3.2
通讯作者：
Vespa P
中科院分区：
文献类型：
--
作者：
Hu X;Glenn T;Scalzo F;Bergsneider M;Sarkiss C;Martin N;Vespa P
我们研究了颅内压（ICP）脉冲形态学指标是否可以用于实现低脑血流的连续检测。本文对63例急性颅脑损伤患者进行了颅内压（ICP）、133氙脑血流（133 XenonCBF）和经颅多普勒（TCD）监测。他们的ICP记录与CBF和TCD测量的时间对齐，以便获得CBF和TCD测量附近的一小时ICP段。这些记录中的每一个通过形态聚类和颅内压分析（MOCAIP）算法处理以提取脉搏形态度量。然后，使用差分进化算法来找到最佳组合的指标，提供，使用正则化线性判别分析，最大的组合的积极的预测性和灵敏度。在CBF阈值为20 ml/min/100 g时，使用常规TCD和血液分析指标的最佳组合作为正则化线性分类器的输入，获得了81.8 ± 0.9%的灵敏度和50.1 ± 0.2%的特异性。然而，单独使用MOCAIP指标的最佳组合能够实现92.5 ± 0.7%的灵敏度和84.8 ± 0.8%的特异性。搜索所有可用指标的最佳组合获得了最佳结果，其略优于单独使用MOCAIP的结果。这项研究表明，ICP监测的潜在作用可能会扩展到提供一个指标，低全球脑血流灌注。
We investigated whether intracranial pressure (ICP) pulse morphological metrics could be used to realize continuous detection of low cerebral blood flow. Sixty-three acutely brain injured patients with ICP monitoring, daily 133Xenon CBF, and daily Transcranial Doppler (TCD) assessment were studied. Their ICP recordings were time-aligned with the CBF and TCD measurements so that an one-hour ICP segment near the CBF and TCD measurement was obtained. Each of these recordings was processed by Morphological Cluster and Analysis of Intracranial Pressure (MOCAIP) algorithm to extract pulse morphological metrics. Then the Differential Evolution algorithm was used to find the optimal combination of the metrics that provided, using the regularized linear discriminant analysis, the largest combined positive predictivity and sensitivity. At a CBF threshold of 20 ml/min/100g, a sensitivity of 81.8 ± 0.9% and specificity of 50.1 ± 0.2% were obtained using the optimal combination of conventional TCD and blood analysis metrics as input to a regularized linear classifier. However, using the optimal combination of the MOCAIP metrics alone was able to achieve a sensitivity of 92.5 ± 0.7% and specificity of 84.8 ± 0.8%. Searching the optimal combination of all available metrics achieved the best result that was marginally better than those from using MOCAIP alone. This study demonstrated that the potential role of ICP monitoring may be extended to provide an indicator of low global cerebral blood perfusion.
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DOI：
10.1109/tbme.2008.2008636
发表时间：
2009-03
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Hu X;Xu P;Scalzo F;Vespa P;Bergsneider M
通讯作者：
Bergsneider M
影响因子：
3.2
作者：
Scalzo, Fabien;Xu, Peng;Asgari, Shadnaz;Bergsneider, Marvin;Hu, Xiao
通讯作者：
Hu, Xiao
影响因子：
8.3
作者：
Sarrafzadeh, AS;Haux, D;Unterberg, AW
通讯作者：
Unterberg, AW
影响因子：
4.7
作者：
Claassen, J;Hirsch, LJ;Mayer, SA
通讯作者：
Mayer, SA
影响因子：
4.1
作者：
AASLID, R;HUBER, P;NORNES, H
通讯作者：
NORNES, H