Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high-cholesterol diet
Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high-cholesterol diet
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DOI：
10.1016/j.febslet.2006.05.041
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发表时间：
2006-06-26
期刊：
影响因子：
3.5
通讯作者：
Watanabe, Tatsuo
中科院分区：
文献类型：
--
作者：
Tomofuji, Takaaki;Azuma, Tetsuii;Watanabe, Tatsuo
研究表明高胆固醇饮食与牙周炎之间存在关联。我们在大鼠模型中探讨了高膳食胆固醇可能损害牙周健康的机制。饲喂高胆固醇饮食会增强细菌病原体及其产物（例如脂多糖和蛋白酶）对成纤维细胞中促炎细胞因子产生的影响。高膳食胆固醇还会增加牙周组织中线粒体 8-羟基脱氧鸟苷的含量。这些结果表明，高膳食胆固醇引起的过度组织氧化损伤可能会增强细菌病原体刺激的成纤维细胞产生促炎细胞因子。 (c) 2006 年欧洲生化学会联合会。由 Elsevier B.V. 出版。保留所有权利。
Studies suggest an association between consumption of a high-cholesterol diet and periodontitis. We addressed the mechanism by which high dietary cholesterol could be detrimental to periodontal health in a rat model. Feeding a high-cholesterol diet augmented the effects of bacterial pathogens and their products (e.g., lipopolysaccharide and proteases) on production of pro-inflammatory cytokines in fibroblasts. High dietary cholesterol also increased mitochondrial 8-hydroxydeoxyguanosine in the periodontal tissues. These results suggest that excessive tissue oxidative damage induced by high dietary cholesterol could potentiate pro-inflammatory cytokine production by fibroblasts stimulated with bacterial pathogens. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.