[Field studies with a new tick-borne encephalitis (TBE) vaccine].
[Field studies with a new tick-borne encephalitis (TBE) vaccine].
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[新型蜱传脑炎（TBE）疫苗的现场研究]。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
A. Stary
中科院分区：
文献类型：
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作者：
C. Kunz;H. Hofmann;A. Stary
使用的疫苗含有福尔马林灭活的TBE病毒，该病毒在鸡胚细胞中生长并吸附到铝凝胶上。在1973年进行的第一项研究中，共有81名志愿者皮下注射两剂疫苗，间隔4周，7-9个月后注射第三剂。每次接种后，在血凝抑制试验中测定血清转化率。获得的值分别为76%、96%和98%。测得的几何平均滴度为1：26、1：36和1：44。该疫苗在局部耐受性良好，仅在首次接种疫苗后记录到发热、头痛和疲劳等全身反应。1974年和1975年，在该病流行的地区，共有30 000人接种了疫苗。大多数接种者在森林中工作，因此感染风险很高。间接证据表明疫苗具有保护作用。
The vaccine used contained formalin-inactivated TBE virus that was grown in chick embryo cells and adsorbed to Alhydrogel. In a first study, conducted in 1973, a total of 81 volunteers were given subcutaneously two doses of vaccine 4 weeks apart, and a third dose 7-9 months later. After each vaccination, the rates of seroconversion were assayed in the hemagglutination inhibition test. The values obtained were 76%, 96% and 98%, respectively. The geometric mean titers found were 1:26, 1:36 and 1:44. The vaccine was well tolerated locally and systematic reactions such as fever headache and fatigue were only recorded after the first dose of vaccine. In 1974 and 1975 a total of 30,000 persons were vaccinated in areas where the disease is endemic. Most of the vaccinees work in forests and are, therefore, at high risk of infection. Circumstantial evidence indicates that the vaccine is protective.