Low-toxicity amphiphilic molecules linked by an aromatic nucleus show broad-spectrum antibacterial activity and low drug resistance
Low-toxicity amphiphilic molecules linked by an aromatic nucleus show broad-spectrum antibacterial activity and low drug resistance
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由芳香核连接的低毒两亲性分子具有广谱抗菌活性和低耐药性
DOI：
10.1039/c9cc00857h
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发表时间：
2019-04-18
影响因子：
4.9
通讯作者：
Zhang, En
中科院分区：
文献类型：
--
作者：
Chu, Wenchao;Yang, Yi;Zhang, En
由芳香核连接的两亲分子对细菌和哺乳动物细胞具有高选择性和低耐药性。一种很有前景的化合物4g对一组敏感和耐药细菌具有很强的杀菌活性，毒性低，能够降低生物膜中的细胞活力，在哺乳动物体液中具有稳定性，能够快速杀死病原体，并且对耐甲氧西林金黄色葡萄球菌（MRSA）具有很高的体内功效。
Amphiphilic molecules linked by an aromatic nucleus were developed that showed high selectivity toward bacteria over mammalian cells, and low drug resistance. A promising compound 4g exhibited strong bactericidal activity against a panel of sensitive and resistant bacteria, low toxicity, the ability to reduce cell viability in biofilms, stability in mammalian fluids, rapid killing of pathogens, and high in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA).