Developmental genetics of the Drosophila egg. I. Identification of 59 sex-linked cistrons with maternal effects on embryonic development.
Developmental genetics of the Drosophila egg. I. Identification of 59 sex-linked cistrons with maternal effects on embryonic development.
复制标题
果蝇卵的发育遗传学。
作者：
J. Mohler
诱发与隐性雌性不育有关的性连锁突变，对产卵进行分类，在广泛的区域内定位，并通过互补试验将其归类为顺反子。这些突变也因其温度敏感性和多效性而被部分表征。共鉴定出59个顺反子，其中包括5个已知基因座：CIN、fs(1)N、MK、sn和r。所有这些基因都对胚胎的发育有母性贡献。在某些情况下，突变缺陷在卵子被膜中被识别；在其余情况下，缺陷可能在卵子细胞质中。对于22个基因的突变，包括CIN、MK和r等位基因，母体效应的致命性被逆转，胚胎通过野生型父系等位基因的作用被拯救。这些突变菌株为研究卵膜发育和进一步分析胚胎发生的原因及其在卵子发生中的起源提供了重要的材料。
Sex-linked mutations to recessive female sterility were induced, sorted for egg-laying, mapped within broad regions and grouped by complementation tests into cistrons. The mutations have also been partially characterized for their temperature sensitivity and pleiotropic effects. Altogether 59 cistrons have been identified, including five ellelic with previously known loci: cin, fs(1)N, mk, sn, and r. All of the genes make maternal contributions to developing embryos. In some instances mutant defects are recognized in the egg envelopes; in the remainder the defects are presumably in the egg cytoplasm. For mutations in twenty-two genes, including cin, mk, and r alleles, the lethality of the maternal effect is reversed and the embryo is "rescued" by the action of a wild-type, paternal allele. The mutant strains are potentially important material for the study of developing egg envelopes and for furthering the analysis of causation in embryogenesis and its origins in oogenesis.