The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue
The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue
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DOI：
10.1038/nsb0297-147
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发表时间：
1997-02-01
期刊：
影响因子：
--
通讯作者：
Webb, MR
中科院分区：
文献类型：
--
作者：
Hirshberg, M;Stockley, RW;Webb, MR
人类 rac1 的晶体结构，它是小 C 蛋白 rho 家族的成员。与不可水解的 GTP 类似物鸟苷-5'-(β-γ-亚氨基)三磷酸 (GMPPNP) 的复合物已通过 X 射线分析以 1.38 埃的分辨率进行测定。与H-ras的结构比较表明，rac1具有额外的α螺旋结构域，这是rho G蛋白的特征，并且可能参与该家族的信号通路。
The crystal structure of human rac1, a member of the rho family of small C-proteins. complexed with the nonhydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 Angstrom. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family.