Cell cycle dependence for the induction of 6-thioguanine-resistant mutations: G2/M stage is distinctively sensitive to 252Cf neutrons but not to 60Co gamma-rays.

Cell cycle dependence for the induction of 6-thioguanine-resistant mutations: G2/M stage is distinctively sensitive to 252Cf neutrons but not to 60Co gamma-rays.
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诱导 6-硫鸟嘌呤抗性突变的细胞周期依赖性:G2/M 阶段对 252Cf 中子特别敏感,但对 60Co 伽马射线不敏感。

DOI:
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发表时间:
1993
影响因子:
2.6
通讯作者:
S. Sawada
S. Sawada
中科院分区:
医学3区
文献类型:
--
作者:
H. Tauchi;N. Nakamura;S. Sawada

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用同步培养的小鼠L5178Y细胞,经4Gy60Co伽马射线或1Gy252Cf(裂变中子)照射后,研究了细胞周期对6-硫鸟嘌呤耐药突变的诱导作用。突变频率在252Cf照射后即刻(G2/M期)达到最大值,而60Coγ射线照射后1h(G1期)突变频率最高。当突变频率与存活率作图时,除了G2/M和G1期外,这两个参数之间存在普遍的相关性,这两个参数在252Cf和60Co辐射的每个致死事件中都更容易发生突变。
Cell cycle dependence for the induction of 6-thioguanine-resistant mutation was investigated using synchronized mouse L5178Y cells after exposure to 4 Gy to 60Co gamma-rays or 1 Gy of 252Cf radiation (fission neutrons). Maximal mutation frequency was observed immediately after release from colcemid block (G2/M phase) after 252Cf radiation, whereas it was 1 h after the release (G1 phase) after 60Co gamma-rays. When the mutation frequency was plotted against the surviving fraction, a general correlation was observed between the two parameters except for G2/M and G1 phases which were more mutable per lethal event for 252Cf and 60Co radiations, respectively.
低剂量率的裂变谱中子增强线性低剂量区域(0-10 cGy)的肿瘤转化。
DOI: 10.1080/09553008414551011
发表时间: 1984
期刊: International journal of radiation biology and related studies in physics, chemistry, and medicine
影响因子: --
作者:
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DOI: --
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