Classical and alternate pathway activation of complement in pemphigus vulgaris lesions.
Classical and alternate pathway activation of complement in pemphigus vulgaris lesions.
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寻常型天疱疮病变中补体的经典和替代途径激活。
DOI：
10.1111/1523-1747.ep12680098
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
Harold O. Perry
中科院分区：
文献类型：
--
作者：
R. E. Jordon;A. L. Schroeter;Roy S. Rogers;Harold O. Perry
采用免疫荧光技术，对6例寻常型天疱疮患者的早期口腔和皮肤病变进行了C1Q、C3、C3前激活物（C3PA）和备解素以及免疫球蛋白（IgG、伊加和IgM）的检查。IgG沉积在病变的正常出现区域和病变的病理区域C1q、C3和C3Pa的细胞间质中，另一方面，仅沉积在有明显血栓溶解的病理区域。备解素沉积仅在2个病灶中明显，然后仅在单个棘层松解细胞周围。伊加定位于细胞间质区仅在口腔病变。这些研究进一步暗示补体系统在寻常型天疱疮的发病机制中的作用。
Early oral and skin lesions from 6 patients with pemphigus vulgaris were examined for the presence of C1Q, C3, C3 proactivator (C3PA), and properdin, in addition to immunoglobulins (IgG, IgA, and IgM), using immunofluorescent techniques. IgG was deposited in the intercellular substance in both normal appearing areas of the lesions and pathologic areas of the lesions C1q, C3, and C3Pa, on the other hand, were deposited only an pathologic areas where acambolysis was evident. Properdin deposits were evident in 2 lesions only, and then only around individual acantholytic cells. IgA localization was seen in intercellular substance areas only in oral lesions. These studies further implicate the complement system in the pathogenesis of pemphigus vulgaris.