Depressive symptoms and the risk of type 2 diabetes mellitus in a US sample
Depressive symptoms and the risk of type 2 diabetes mellitus in a US sample
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DOI：
10.1002/dmrr.353
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发表时间：
2003-05-01
影响因子：
8
通讯作者：
Harris, MI
中科院分区：
文献类型：
--
作者：
Saydah, SH;Brancati, FL;Harris, MI
目的 有一些证据表明，患有抑郁症的人患 2 型糖尿病的风险几乎增加了一倍，但结果还远未得出结论。因此，为了确定抑郁症状是否会增加患 2 型糖尿病的风险，我们利用 NHANES I 流行病学随访调查 (NHEFS) 的数据进行了纵向分析。 研究设计和方法 参与者包括白人或非裔美国人、未报告既往糖尿病诊断以及在 1982-1984 年研究中完成流行病学研究中心抑郁症 (CES-D) 调查问卷的个体 (n = 8870)。参与者对事件诊断的糖尿病进行了随访直至 1992 年（平均随访 9.0 年）。结果 在 1982-1984 年的研究中，有 1444 名（15.9%）参与者患有高度抑郁症状（CES-D 评分大于或等于 16）。随访期间，共有 465 例糖尿病病例。重度抑郁症状患者的糖尿病发病率为 6.9/1000 人年，中度抑郁症状患者的糖尿病发病率为 6.0/1000 人年，无症状患者的糖尿病发病率为 5.0/1000 人年。调整年龄、性别和种族后，与没有症状的人相比，有高度抑郁症状的人患糖尿病的相对风险 (RH) 为 1.27（95% CI：0.93 至 1.73）。对教育程度和已知糖尿病危险因素（体重指数和体力活动）的进一步调整进一步削弱了这种关系（RH 1.11，95% Cl：0.79至1.56）。 结论 与没有抑郁症状的人相比，有高度或中度抑郁症状的人糖尿病发病率没有增加。这些结果并不支持抑郁症使个体易患糖尿病的病因关系。版权所有 (C) 2002 John Wiley Sons, Ltd.
Objective There is some evidence to suggest that individuals with depression are at an almost twofold increased risk of developing type 2 diabetes mellitus, but results are far from conclusive. Therefore, to determine if depressive symptoms increased the risk of type 2 diabetes, we conducted longitudinal analyses using data from the NHANES I Epidemiologic Follow-up Survey (NHEFS).Research design and methods Participants included individuals who were white or African-American, did not report previous diagnosis of diabetes, and who completed the Centers for Epidemiologic Studies Depression (CES-D) questionnaire in the 1982-1984 study (n = 8870). Participants were followed up for incident-diagnosed diabetes through 1992 (mean follow-up 9.0 years).Results There were 1444 (15.9%) participants with high depressive symptoms in the 1982-1984 study (CES-D score greater than or equal to 16). During follow-up, there were 465 incident cases of diabetes. Incidence of diabetes was 6.9/1000 person years among those with high depressive symptoms, 6.0/1000 person years among those with moderate symptoms, and 5.0/1000 person years among those with no symptoms. After adjusting for age, sex, and race, the relative hazard (RH) of diabetes among those with high depressive symptoms was 1.27 (95% Cl: 0.93 to 1.73) compared to those without symptoms. Further adjustment for education and known diabetes risk factors (body mass index and physical activity) further attenuated the relationship (RH 1.11, 95% Cl: 0.79 to 1.56).Conclusions There was no increased incidence of diabetes for those with high or moderate depressive symptoms compared to those with no depressive symptoms. These results do not support the etiologic relationship of depression predisposing individuals to diabetes. Copyright (C) 2002 John Wiley Sons, Ltd.