HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: Findings and implications for vaccine design
HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: Findings and implications for vaccine design
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DOI：
10.1016/j.vaccine.2007.01.020
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发表时间：
2007-04-20
期刊：
影响因子：
5.5
通讯作者：
Poland, Gregory A.
中科院分区：
文献类型：
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作者：
Ovsyannikova, Inna G.;Jacobson, Robert M.;Poland, Gregory A.
虽然麻疹-腮腺炎-风疹（MMR）疫苗接种的免疫应答结果取决于多种因素，但必须阐明特定宿主遗传标记，例如基于HLA分子肽结合口袋中共享序列基序的HLA超型。我们研究了346名先前接受过两剂MMR免疫的儿童的不道德和细胞免疫应答与HLA超型之间的关系。我们发现，HLA超型，如A3，B7，B44，B58，B62，和DR可能在调节免疫反应的麻疹和腮腺炎成分的MMR疫苗。这一信息可能是工程的潜在的基于表位的疫苗，被人HLA超型等位基因限制的T细胞识别的显着价值。(c)2007爱思唯尔有限公司保留所有权利。
Although the outcome of the immune response to measles-mumps-rubella (MMR) vaccination depends on multiple factors, elucidation of specific host genetic markers, such as HLA supertypes based on a shared sequence motif in the peptide-binding pockets of HLA molecules, is essential. We studied the association between measures of Immoral and cellular immune responses and HLA supertypes among 346 children previously immunized with two doses of MMR. We found that HLA supertypes, such as A3, B7, B44, B58, B62, and DR may play a role in modulating immune responses to the measles and mumps components of MMR vaccine. This information may be of significant value in the engineering of potential epitope-based vaccines that are recognized by T cells restricted by human HLA supertype alleles. (c) 2007 Elsevier Ltd. All rights reserved.