Pathogen-dependent induction of cytokines and other soluble inflammatory mediators during intramammary infection of dairy cows
Pathogen-dependent induction of cytokines and other soluble inflammatory mediators during intramammary infection of dairy cows
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DOI：
10.2527/jas.2008-1187
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发表时间：
2009-04-01
影响因子：
3.3
通讯作者：
Bannerman, D. D.
中科院分区：
文献类型：
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作者：
Bannerman, D. D.
乳腺炎是奶牛的一种高度流行和昂贵的疾病，通常由乳房内细菌感染引起。在感染后数小时内诱发对细菌侵入乳腺的先天免疫应答，并且已经证明这种应答的速度和幅度影响这种疾病的解决。已知细胞因子和其他炎症介质在对乳房内感染的先天免疫应答中起关键作用。本综述的目的是总结目前的理解细胞因子对乳房内感染的反应，突出最近的发现，确定不同的细胞因子对各种细菌病原体的反应的差异，并讨论未来的研究方向，将增加我们的知识的炎症介质的作用，在预测和管理乳腺炎的结果。
Mastitis is a highly prevalent and costly disease of dairy cows that is commonly caused by intramammary bacterial infection. The innate immune response to bacterial penetration of the mammary gland is evoked within hours of infection, and the rapidity and magnitude of this response have been demonstrated to influence the resolution of this disease. Cytokines and other mediators of inflammation are known to play critical roles in the innate immune response to intramammary infection. The objectives of this review are to summarize the current understanding of the cytokine response to intramammary infection, highlight recent findings identifying differences in the cytokine response to various bacterial pathogens, and discuss future research directions that will increase our knowledge of the role of inflammatory mediators in predicting and governing the outcome of mastitis.