Palladium-Catalyzed C( sp3)- H Activation: A Facile Method for the Synthesis of 3,4-Dihydroquinolinone Derivatives**
Palladium-Catalyzed C( sp3)- H Activation: A Facile Method for the Synthesis of 3,4-Dihydroquinolinone Derivatives**
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DOI：
10.1002/anie.201402562
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发表时间：
2014-05-05
影响因子：
16.6
通讯作者：
Shi, Zhang-Jie
中科院分区：
文献类型：
--
作者：
Yan, Jia-Xuan;Li, Hu;Shi, Zhang-Jie
通过钯催化、氧化加成引发的惰性C（sp（3））H键活化和芳基化反应合成了3，4-二氢喹啉酮。为了提高反应效率，分别采用Pd（OAc）（2）和P（o-tol）（3）作为催化剂和配体。该反应的另一个优点是它可以在空气中进行。一个相对罕见的七元钯配合物被认为是催化循环的关键中间体。
3,4-Dihydroquinolinones were synthesized by the palladium-catalyzed, oxidative-addition-initiated activation and arylation of inert C(sp(3))H bonds. Pd(OAc)(2) and P(o-tol)(3) were used as the catalyst and ligand, respectively, to improve the efficiency of the reaction. A further advantage of this reaction is that it could be performed in air. A relatively rare seven-membered palladacycle was proposed as a key intermediate of the catalytic cycle.