Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC)
Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC)
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DOI：
10.1002/ijc.24948
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发表时间：
2010-06-01
影响因子：
6.4
通讯作者：
Hegyi, Ivan
中科院分区：
文献类型：
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作者：
Albinger-Hegyi, Andrea;Stoeckli, Sandro J.;Hegyi, Ivan
赖氨酰氧化酶(LOX)家族的蛋白质是细胞外基质的重要调节物。然而，它们在肿瘤的发展以及肿瘤的进展中都起着重要的作用。为了评价LOX蛋白在口腔和口咽鳞状细胞癌(OSCC)中的诊断和预后价值，我们对两个组织芯片(共622个组织样本)进行了QRT-PCR和免疫组织化学分析。与正常口腔黏膜相比，高度发育不良口腔黏膜和口腔鳞癌组织中LOX的表达均显著升高(P<；0.001)。LOX的高表达与临床TNM分期(P=0.020)、整个队列中的淋巴结转移(P<；0.001)以及小原发肿瘤亚组(T1/12，P<；0.001)相关。此外，LOX高表达与总生存率低(P=0.004)和疾病特异性生存率低(P=0.037)相关。在多变量分析中，LOX的高表达是一个独立的预后因素，预示着不良的总体生存。综上所述，LOX表达是口腔鳞癌中一个独立的预后生物标志物和淋巴结转移的预测因子。此外，LOX的过度表达可能是口腔鳞癌发病机制中的早期现象，因此是化学预防和治疗策略的一个有吸引力的新靶点。
Proteins of the lysyl oxidase (LOX) family are important modulators of the extracellular matrix. However, they have an important role in the tumour development as well as in tumour progression. To evaluate the diagnostic and prognostic value of the LOX protein in oral and oropharyngeal squamous cell carcinoma (OSCC) we performed QRT-PCR and immunohistochemical analysis on two tissue microarrays (622 tissue samples in total). Significantly higher LOX expression was detected in high grade dysplastic oral mucosa as well as in OSCC when compared to normal oral mucosa (P < 0.001). High LOX expression was correlated with clinical TNM stage (P = 0.020), lymph node metastases for the entire cohort (P < 0.001), as well as in the subgroup of small primary tumours (T1/12, P < 0.001). Moreover, high LOX expression was correlated with poor overall survival (P = 0.004) and disease specific survival (P = 0.037). In a multivariate analysis, high LOX expression was an independent prognostic factor, predicting unfavourable overall survival. In summary, LOX expression is an independent prognostic biomarker and a predictor of lymph node metastasis in OSCC. Moreover, LOX overexpression may be an early phenomenon in the pathogenesis of OSCC and thus an attractive novel target for chemopreventive and therapeutic strategies.