An MR-based technique for quantifying the deformation of articular cartilage during mechanical loading in an intact cadaver joint
An MR-based technique for quantifying the deformation of articular cartilage during mechanical loading in an intact cadaver joint
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DOI：
10.1002/mrm.1910390522
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发表时间：
1998-05-01
影响因子：
3.3
通讯作者：
Eckstein, F
中科院分区：
文献类型：
--
作者：
Herberhold, C;Stammberger, T;Eckstein, F
本研究的目的是开发一种基于MR的技术，用于在高空间和时间分辨率下量化完整尸体关节中机械载荷期间关节软骨的变形。构建了一种非金属压力装置，用于在临床1.5 T MRI扫描仪的肢体线圈内向股-髌关节施加>1000 N的载荷。数字图像处理方法被用来确定连续的2D脂肪抑制FLASH图像中的位置和时间依赖性软骨变形。此外，从3D脂肪抑制的FLASH图像数据进行软骨的三维重建。在静态压缩的前10分钟期间，观察到厚度变化在10%和30%之间。3小时后，记录到厚度变化大于50%，体积变化20%。该技术允许在其自然环境中的关节软骨的负载和时间依赖性的力学行为的分析。
The objective of this study was to develop an MR-based technique for quantifying the deformation of articular cartilage during mechanical loading in an intact cadaver joint at high spatial and temporal resolution, A nonmetallic pressure device was constructed for applying loads of >1000 N to a femoro-patellar articulation within an extremity coil of a clinical 1.5 T MRI scanner. Digital image processing methods were used to determine the location-and time-dependent cartilage deformation in consecutive 2D fat-suppressed FLASH images. Additionally, three-dimensional reconstruction of the cartilage was performed from 3D fat-suppressed FLASH image data. During the first 10 min of static compression, thickness changes between 10 and 30% were observed. Thickness changes greater than 50% and volume changes of 20% were recorded after 3 h. The technique permits analysis of the load and time-dependent mechanical behavior of articular cartilage in its natural environment.