Viral aetiology of lower respiratory tract infection in young Malaysian children
Viral aetiology of lower respiratory tract infection in young Malaysian children
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DOI：
10.1046/j.1440-1754.1999.00359.x
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发表时间：
1999-06-01
影响因子：
1.7
通讯作者：
Hooi, PS
中科院分区：
文献类型：
--
作者：
Chan, PWK;Goh, AYT;Hooi, PS
目的：研究马来西亚幼年儿童下呼吸道感染(LRTI)的病原学。方法：对1982~1997年间马来亚大学医学中心收治的24个月以下LRTI患儿进行回顾性分析。通过间接免疫荧光法和/或病毒培养法检测鼻咽分泌物中的呼吸道病毒。结果：共有5691名儿童纳入研究。平均年龄为8.6+/-6.6个月，男女比例为1.6.1。最常见的诊断是肺炎(52%)，其次是毛细支气管炎(45%)和咽喉炎(2%)。病毒分离阳性率为22.0%。呼吸道合胞病毒(RSV)是最常见的病毒(84%)，其次是副流感病毒(8%)，流感病毒(6%)和腺病毒(2%)。病毒分离阳性的患者年龄较小(7·8+/-6·2个月vs8·7+/-6·7个月，P=0.0001)，更容易发生毛细支气管炎。
Objective: To study the viral aetiology of lower respiratory tract infection (LRTI) in young Malaysian children.Methodology: A retrospective review was performed of LRTI patients aged less than 24 months who were admitted to the University Malaya Medical Centre between 1982 and 1997. Respiratory viruses in their nasopharyngeal secretion were identified by indirect immunofluorescence, viral culture, or both.Results: A total of 5691 children were included in the study. The mean age was 8.6 +/- 6.6 months and the M:F ratio was 1.6.1. The most common diagnosis was pneumonia (52%) followed by bronchiolitis (45%) and croup (2%). Positive viral isolation rate was 22.0%. Respiratory syncytial virus (RSV) was the commonest virus isolated (84%), followed by parainfluenza virus (8%), influenza virus (6%) and adenovirus (2%). Patients with positive virus isolation were younger (7.8 +/- 6.2 vs 8.7 +/- 6.7 months, P = 0.0001) and were more likely to have bronchiolitis.Conclusion: Young Malaysian children admitted with LRTI had a 22% viral isolation rate and RSV was the commonest virus isolated.