Serum parathyroid hormone (PTH) in pregnant women determined by an immunoradiometric assay for intact PTH.
Serum parathyroid hormone (PTH) in pregnant women determined by an immunoradiometric assay for intact PTH.
复制标题
通过免疫放射测定完整 PTH 测定孕妇血清甲状旁腺激素 (PTH)。
DOI：
10.1210/jcem-67-4-850
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
I. Schiff
中科院分区：
文献类型：
--
作者：
O. Davis;D. S. Hawkins;L. Rubin;J. Posillico;E. Brown;I. Schiff
大多数使用传统 RIA 进行的循环 PTH 水平研究都支持妊娠期生理性甲状旁腺功能亢进的概念，即孕妇的血清免疫反应性 PTH 水平显着高于非妊娠受试者。然而，此类RIAs不敏感，并且经常检测到无活性的PTH片段，因此PTH免疫反应性和生物活性之间的相关性较差。采用新的完整 PTH 免疫放射测定法 (Allegro-Nichols)，我们重新评估了妊娠对甲状旁腺功能的影响。 81 名孕妇的平均血清 PTH 水平为 14.4 +/- 6.3 (+/- SD)，而 11 名正常周期非孕妇的平均血清 PTH 水平为 24.8 +/- 9.0 ng/L（P 小于 0.001）。两组的平均血清总钙和离子钙水平相似。通过细胞化学生物测定法测定，5 名孕妇的血清生物活性 PTH（7.7 +/- 3.4 ng/L）略低于正常个体（11.1 +/- 1.9 ng/L）。我们的研究结果表明，与大多数先前研究的结果相反，血清完整 PTH 在怀孕期间可能会下降。
Most studies of circulating PTH levels using traditional RIAs have supported the concept of physiological hyperparathyroidism of pregnancy, with pregnant women having serum immunoreactive PTH levels significantly higher than those in nonpregnant subjects. However, such RIAs are insensitive and often detect inactive PTH fragments, so that the correlation between PTH immunoreactivity and bioactivity is poor. Employing a new intact PTH immunoradiometric assay (Allegro-Nichols), we reassessed the effects of pregnancy on parathyroid function. The mean serum PTH level in 81 pregnant women was 14.4 +/- 6.3 (+/- SD) compared to 24.8 +/- 9.0 ng/L in 11 normally cycling nonpregnant women (P less than 0.001). The mean serum total and ionized calcium levels in the 2 groups were similar. In 5 of the pregnant women, serum bioactive PTH, determined by cytochemical bioassay, was slightly lower (7.7 +/- 3.4 ng/L) than in normal individuals (11.1 +/- 1.9 ng/L). Our findings suggest, in contrast with the results of most previous studies, that serum intact PTH may decline during pregnancy.
人胎盘产生 1α,25-二羟基维生素 D3：正常受试者和假性甲状旁腺功能减退症患者的生化特征和产生。
DOI：
10.1210/jcem-62-1-192
发表时间：
1986
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Zerwekh,JE;Breslau,NA
通讯作者：
Breslau,NA
影响因子：
5.8
作者：
BRESLAU, NA;ZERWEKH, JE
通讯作者：
ZERWEKH, JE