LARGE ANIMAL-MODEL OF LEFT-VENTRICULAR ANEURYSM
LARGE ANIMAL-MODEL OF LEFT-VENTRICULAR ANEURYSM
复制标题
DOI：
10.1016/0003-4975(89)90682-6
复制
发表时间：
1989-12-01
影响因子：
4.6
通讯作者：
EDMUNDS, LH
中科院分区：
文献类型：
--
作者：
MARKOVITZ, LJ;SAVAGE, EB;EDMUNDS, LH
在28只Dorsett绵羊中，结扎远端左冠状动脉（相当于人类左前降支）和第二对角冠状动脉产生了22.9%的持续透壁性梗死。2.5%（平均值±）标准偏差）。连续左心室造影显示，在4小时内，所有绵羊的梗死段扩大，壁厚度减少，并在接下来的60天内发生和发展动脉瘤扩张。心外膜心室点参考表明，相邻的非梗死心肌参与了动脉瘤的形成。在22只离体绵羊心脏上，对冠状动脉进行了解剖学研究。在绵羊中，冠状动脉解剖结构非常恒定。左冠状动脉为左心室和室间隔提供所有的血液供应，并且仅为前右心室和后右心室提供小的边缘。心脏静脉从左心室流入冠状窦，冠状窦也接受左奇静脉。右心室静脉分别引流。基本上可分离的冠状动脉循环到两个心室，冠状动脉侧支循环的缺乏，以及左心室梗死到动脉瘤的一致演变是绵羊模型的重要优势，用于急性心肌梗死和左心室动脉瘤的代谢和心室机械研究。
In 28 Dorsett sheep, ligation of the distal homonymous (equivalent to human left anterior descending) and second diagonal coronary arteries produced a constant transmural infarct of 22.9% .+-. 2.5% (mean .+-. standard deviation) of the left ventricular mass. Serial left ventriculograms showed that within four hours the infarct segment expands, wall thickness decreases, and aneurysmal dilatation occurs and progresses over the next 60 days in all sheep. Epicardial ventricular point references indicated that adjacent noninfarcted myocardium participates in the formation of the aneurysm. Anatomy of the coronary vasculature was studied in 22 excised sheep hearts. In sheep, coronary arterial anatomy is remarkably constant. The left coronary artery provides all of the blood supply to the left ventricle and septum and only a small rim of both the anterior and posterior right ventricules. Cardiac veins from the left ventricle drain into the coronary sinus, which also receives the left azygos vein. Right ventricular veins drain separately. The essentially separable coronary circulations to the two ventricles, the paucity of coronary collateral circulation, and the consistent evolution of left ventricular infarcts into aneurysms are important advantages of the ovine model for both metabolic and ventricular mechanical studies of acute myocardial infarction and left ventricular aneurysm.