Expression of amphiregulin and epidermal growth factor receptor in human breast cancer:: analysis of autocriny and stromal-epithelial interactions
Expression of amphiregulin and epidermal growth factor receptor in human breast cancer:: analysis of autocriny and stromal-epithelial interactions
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DOI：
10.1002/path.902
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发表时间：
2001-08-01
影响因子：
7.3
通讯作者：
Calvo, F
中科院分区：
文献类型：
--
作者：
Ma, L;de Roquancourt, A;Calvo, F
通过双重免疫染色对一系列 84 例浸润性导管乳腺癌样本（其中 33 例来自局部晚期炎症 (T4d) 癌症）中的双调蛋白 (AR) 及其受体表皮生长因子受体 (EGFR) 进行评估。 AR 和 EGFR 的共表达总是在肿瘤邻近的非恶性乳腺组织中发现 (24/24)。或者，在 50% 的侵袭性上皮肿瘤细胞中发现 AR 和 EGFR 表达。和 17.8% 的样本。在肿瘤间质中，分别为59.5%和30.9%。的样本分别呈阳性染色。通过单变量分析，浸润性癌中的 AR 和 EGFR 表达与肿瘤体积大、炎性癌、淋巴结受累、Bloom-Richardson (SBR) III 级和雌激素受体缺失相关。基质细胞中的 EGFR 表达与非炎性癌相关。在 14.3% 的病例中检测到在浸润性癌中存在 AR 和 EGFR 表达的推定自分泌环。在 11.9% 的病例中检测到侵袭性肿瘤细胞中 AR 基质表达和 EGFR 表达，并且与不良预后参数相关。通过多变量分析，侵袭性肿瘤中的 AR 表达与炎性癌密切相关（p = 0.005），与 SBR III 级相关（p = 0.07）。侵袭性肿瘤和基质细胞中的 EGFR 表达与雌激素受体缺失和非炎性癌相关（分别为 p = 0.002 和 p = 0.015）。版权所有 (C) 2001 John Wiley & Sons, Ltd.
Amphiregulin (AR) and its receptor, epidermal growth factor receptor (EGFR), were e-valuated by dual immunostaining in a series of 84 invasive ductal breast carcinoma specimens, 33 of which were from locally advanced inflammatory (T4d) cancer. Co-expression of AR and EGFR was always found in non-malignant breast tissues adjacent to tumours (24/24). Alternatively, expression of AR and EGFR was found in invasive epithelial tumour cells in 50%. and 17.8% of specimens, respectively. In tumour stroma, 59.5%, and 30.9%. of specimens, respectively, were positively stained. By univariate analysis, AR and EGFR expression in invasive carcinomas was correlated with large tumour size, inflammatory carcinoma, node involvement, Bloom-Richardson (SBR) grade III, and absence of oestrogen receptor. EGFR expression in stromal cells was correlated with non-inflammatory carcinoma. A putative autocrine loop with AR and EGFR expression in invasive carcinoma was detected in 14.3%,, of cases. Stromal expression of AR and EGFR expression in invasive tumour cells was detected in 11.9% of cases and related to poor prognostic parameters. By multivariate analysis, AR expression in invasive tumour was strongly related to inflammatory carcinoma (p = 0.005) and marginally related to SBR grade III (p = 0.07). EGFR expression in invasive tumour and stromal cells was correlated with absence of oestrogen receptor and non-inflammatory carcinoma (p = 0.002 and p = 0.015, respectively). Copyright (C) 2001 John Wiley & Sons, Ltd.