Reduction in Levels of Plasma Vascular Endothelial Growth Factor-A and Improvement in Hydrocele Patients by Targeting Endosymbiotic Wolbachia sp in Wuchereria bancrofti with Doxycycline
Reduction in Levels of Plasma Vascular Endothelial Growth Factor-A and Improvement in Hydrocele Patients by Targeting Endosymbiotic Wolbachia sp in Wuchereria bancrofti with Doxycycline
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DOI：
10.4269/ajtmh.2009.80.956
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发表时间：
2009-06-01
影响因子：
3.3
通讯作者：
Hoerauf, Achim
中科院分区：
文献类型：
--
作者：
Debrah, Alexander Y.;Mand, Sabine;Hoerauf, Achim
鞘膜积液的治疗是昂贵的侵入性手术-鞘膜积液切除术。一种可以预防或改善这种情况的药物可以替代或补充脑积水切除术。在加纳，42名鞘膜积液患者参加了一项双盲、安慰剂对照试验，他们接受了为期6周的强力霉素治疗，剂量为200毫克/天。强力霉素治疗4个月后。患者给予伊维菌素150 μ g/kg，阿苯达唑400 mg，用于该地区的大规模化疗。监测患者沃尔巴克氏体、微丝虫病、抗原血症、血浆血管内皮生长因子- a （VEGF-A）水平和鞘膜积液的分期/大小。与安慰剂组相比，多西环素治疗的患者沃尔巴克氏菌载量/微丝虫病、微丝虫病和抗原血症显著降低。在多西环素治疗的活动性感染患者中，VEGF-A的平均血浆水平显著降低。这一发现先于鞘膜积液期的缩短。一项为期六周的强力霉素治疗丝虫病的方案显示改善了活动性感染的鞘膜积液患者的病理状况。
The treatment for hydrocele is expensive, invasive surgery-hydrocelectomy. A drug that could prevent or improve this condition could replace or supplement hydrocelectomy. In Ghana, 42 hydrocele patients participated in a double-blind, placebo-controlled trial of a six-week regimen of doxycycline, 200 mg/day. Four months after doxycycline treatment. patients received 150 mu g/kg of ivermectin and 400 mg of albendazole, which is used for mass chemotherapy in this area. Patients were monitored for levels of Wolbachia sp., microfilaremia, antigenemia, plasma levels of vascular endothelial growth factor-A (VEGF-A) and stage/size of the hydrocele. Wolbachia sp. loads/microfilaria, microfilaremia, and antigenemia were significantly reduced in the doxycycline-treated patients compared with the placebo group. The mean plasma levels of VEGF-A were decreased significantly in the doxycycline-treated patients who had active infection. This finding preceded the reduction of the stage of hydrocele. A six-week regimen of doxycycline treatment against filariasis showed amelioration of pathologic conditions of hydrocele patients with active infection.