Breakthroughs in cell therapy for heart disease: focus on cardiosphere-derived cells.
Breakthroughs in cell therapy for heart disease: focus on cardiosphere-derived cells.
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DOI：
10.1016/j.mayocp.2014.02.014
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发表时间：
2014-06
影响因子：
8.9
通讯作者：
Marbán E
中科院分区：
文献类型：
--
作者：
Marbán E
心脏病细胞疗法的临床现实可以追溯到 20 世纪 90 年代，当时在开胸手术中首次将自体骨骼成肌细胞移植到衰竭的心脏中。从那时起，焦点转向了骨髓来源的细胞，最近又转向了从心脏本身提取的细胞。尽管进展是非线性的并且常常令人沮丧，但该领域仍然取得了显着的进展。六大突破引人注目：1）建立冠状动脉内分娩的安全性； 2）证明治疗性再生是可能的； 3）同种异体细胞疗法的兴起； 4）增加机械洞察力的影响； 5）临床疗效的曙光； 6) 进入 2 期和 3 期研究的进展。在这里，我将分别详细回顾这些具有里程碑意义的发展。总的来说，我得出的结论是，该领域已经达到了一个新的成熟阶段，临床影响的前景越来越迫在眉睫。
The clinical reality of cell therapy for heart disease dates back to the 1990s, when autologous skeletal myoblasts were first transplanted into failing hearts during open-chest surgery. Since then, the focus has shifted to bone marrow-derived cells and, more recently, cells extracted from the heart itself. While progress has been nonlinear and often disheartening, the field has nevertheless made remarkable progress. Six major breakthroughs are notable: 1) The establishment of safety with intracoronary delivery; 2) The demonstration that therapeutic regeneration is possible; 3) The rise of allogeneic cell therapy; 4) The impact of increasing mechanistic insights; 5) Glimmers of clinical efficacy; and 6) The progression to phase 2&3 studies. Here I review these landmark developments individually in some detail. Collectively, I conclude that the field has reached a new phase of maturity where the prospect of clinical impact is increasingly imminent.
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影响因子：
9.5
作者：
Hong KU;Li QH;Guo Y;Patton NS;Moktar A;Bhatnagar A;Bolli R
通讯作者：
Bolli R
影响因子：
3.7
作者：
Davis DR;Zhang Y;Smith RR;Cheng K;Terrovitis J;Malliaras K;Li TS;White A;Makkar R;Marbán E
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Marbán E
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Makkar, Raj R.;Smith, Rachel R.;Cheng, Ke;Malliaras, Konstantinos;Thomson, Louise E. J.;Berman, Daniel;Czer, Lawrence S. C.;Marban, Linda;Mendizabal, Adam;Johnston, Peter V.;Russell, Stuart D.;Schuleri, Karl H.;Lardo, Albert C.;Gerstenblith, Gary;Marban, Eduardo
通讯作者：
Marban, Eduardo
影响因子：
39.3
作者：
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通讯作者：
Makikallio, Timo H.
影响因子：
5.2
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通讯作者：
Marban, Eduardo