Naloxone does not increase the minimum alveolar anesthetic concentration of sevoflurane in mice
Naloxone does not increase the minimum alveolar anesthetic concentration of sevoflurane in mice
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DOI：
10.1213/01.ane.0000204254.87933.f6
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发表时间：
2006-05-01
影响因子：
5.7
通讯作者：
Sonner, JM
中科院分区：
文献类型：
--
作者：
Liao, M;Laster, MJ;Sonner, JM
先前的几项研究得出结论，阿片受体并不介导吸入麻醉剂在面对伤害性刺激时产生静止的能力，因为纳洛酮(一种非特异性阿片受体拮抗剂)的使用不会增加吸入麻醉剂的最低肺泡麻醉浓度(MAC)，在50%的受试者受到伤害性刺激时，吸入麻醉剂会产生静止。相比之下，最近的一项研究发现，小鼠腹腔注射0.1 mg/kg纳洛酮可使七氟醚MAC增加18%(P<；0.01)。我们在相同品系的小鼠身上重复了最近对七氟醚进行的研究，不给予任何(对照)、0.1 mg/kg和1.0 mg/kg纳洛酮。我们的研究的不同之处在于，我们还测试了一组平行的患者，他们给予的是生理盐水，而不是纳洛酮。我们对药物管理视而不见。第一次和第二次注射生理盐水后，MAC分别下降4.8%+/-1.1.0%(平均值+/-SD)和2.4%+/-12.5%。同样，0.1 mg/kg和1.0 mg/kg纳洛酮组的MAC分别下降4.7%+/-7.1%和5.5%+/-10.0%。我们没有发现纳洛酮增加MAC。阿片受体并不是吸入性麻醉剂产生静止的部分能力的基础。
Several previous studies concluded that opioid receptors do not mediate the capacity of inhaled anesthetics to produce immobility in the face of noxious Stimulation because administration of naloxone (a nonspecific opioid receptor antagonist) does not increase the minimum alveolar anesthetic concentration (MAC) of inhaled anesthetic that produces immobility in 50% of subjects given a noxious stimulation. In contrast, a recent study found that 0.1 mg/kg naloxone given intraperitoneally increased sevoflurane MAC in mice by 18% (P < 0.01). We repeated the recent study with sevoflurane in the same strain of mice, administering nothing (control), 0.1 mg/kg, and 1.0 mg/kg of naloxone. Our study differed in that we also tested a parallel group given saline rather than naloxone. We were blinded to drug administration. MAC decreased 4.8% +/- 1.1.0% (mean +/- SD) and 2.4% +/- 12.5% with the first and second administrations of saline. Similarly, MAC decreased 4.7% +/- 7.1% and 5.5% +/- 10.0% with the administration of 0.1 mg/kg and 1.0 mg/kg of naloxone. We do not find that naloxone increases MAC. Opioid receptors do not underlie a portion of the capacity of inhaled anesthetics to produce immobility.