Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
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DOI：
10.1101/gad.845700
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发表时间：
2000-11-01
影响因子：
10.5
通讯作者：
Hafen, E
中科院分区：
文献类型：
--
作者：
Oldham, S;Montagne, J;Hafen, E
生长对营养变化的适应对于所有生物体的正常发育是必不可少的。在这里，我们描述了鉴定的果蝇同源物的目标雷帕霉素（TOR），一个候选效应器的营养传感。遗传和生化分析表明，dTOR通过调节dS6K的活性自主影响生长来影响胰岛素信号传导途径。然而，与胰岛素信号传导途径中的其他组分相比，dTOR功能的部分丧失优先降低了内复制组织的生长。这些结果与dTOR驻留在平行氨基酸传感途径上一致。
The adaptation of growth in response to nutritional changes is essential for the proper development of all organisms. Here we describe the identification of the Drosophila homolog of the target of rapamycin (TOR), a candidate effector for nutritional sensing. Genetic and biochemical analyses indicate that dTOR impinges on the insulin signaling pathway by autonomously affecting growth through modulating the activity of dS6K. However, in contrast to other components in the insulin signaling pathway, partial loss of dTOR function preferentially reduces growth of the endoreplicating tissues. These results are consistent with dTOR residing on a parallel amino acid sensing pathway.