Untangling Galectin-Mediated Circuits that Control Hypoxia-Driven Angiogenesis.
Untangling Galectin-Mediated Circuits that Control Hypoxia-Driven Angiogenesis.
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DOI：
10.1007/978-1-0716-2055-7_34
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发表时间：
2022-01-01
期刊：
影响因子：
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通讯作者：
Croci, Diego O
中科院分区：
文献类型：
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作者：
Bannoud, Nadia;Garcia, P Alfredo;Croci, Diego O
异常血管网络的发展是肿瘤生长和转移的多步骤病理过程的标志。在对缺氧的反应中，一些促血管生成因子被合成以支持癌症进展所需的血管化程序。新出现的数据表明，聚糖和聚糖结合蛋白是健康和疾病中血管回路的关键调节因子。凝血素可能受到缺氧条件的调节，并在不同的生理病理条件下控制血管生成。这些β -半乳糖苷结合蛋白可能通过与不同的糖基化受体相互作用并触发不同的信号通路来促进发芽血管生成。了解凝集素在肿瘤新生血管中的作用将有助于设计新的抗血管生成疗法，以补充当前的抗癌模式并克服对这些治疗的耐药性。在这里，我们描述了用于研究缺氧调节的凝集素在血管形成调节中的作用的选择策略和方法。
Development of an aberrant vascular network is a hallmark of the multistep pathological process of tumor growth and metastasis. In response to hypoxia, several pro-angiogenic factors are synthesized to support vascularization programs required for cancer progression. Emerging data indicate the involvement of glycans and glycan-binding proteins as critical regulators of vascular circuits in health and disease. Galectins may be regulated by hypoxic conditions and control angiogenesis in different physiopathological settings. These beta-galactoside-binding proteins may promote sprouting angiogenesis by interacting with different glycosylated receptors and triggering distinct signaling pathways. Understanding the role of galectins in tumor neovascularization will contribute to the design of novel anti-angiogenic therapies aimed at complementing current anti-cancer modalities and overcoming resistance to these treatments. Here we describe selected strategies and methods used to study the role of hypoxia-regulated galectins in the regulation of blood vessel formation.