Relay Catalysis by Achiral Borane and Chiral Phosphoric Acid in the Metal-Free Asymmetric Hydrogenation of Chromones
Relay Catalysis by Achiral Borane and Chiral Phosphoric Acid in the Metal-Free Asymmetric Hydrogenation of Chromones
复制标题
非手性硼烷和手性磷酸在色酮的无金属不对称氢化中的中继催化。
DOI：
10.1021/acs.orglett.1c03286
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发表时间：
2021-10-20
期刊：
影响因子：
5.2
通讯作者：
Du, Haifeng
中科院分区：
文献类型：
--
作者：
Chen, Jingjing;Gao, Bochao;Du, Haifeng
成功开发了非手性硼烷和手性磷酸的中继催化策略，用于色酮的不对称氢化，以高达 95% ee 的高收率得到所需产物。非手性硼烷和手性磷酸在此反应中高度相容。非手性硼烷充当第一步氢化的路易斯酸，手性磷酸充当有效的手性质子梭以控制对映选择性。
A strategy of relay catalysis by achiral borane and chiral phosphoric acid was successfully developed for the asymmetric hydrogenation of chromones, giving the desired products in high yields with up to 95% ee. Achiral borane and chiral phosphoric acid are highly compatible in this reaction. The achiral borane acts as a Lewis acid for the first-step hydrogenation, and the chiral phosphoric acid acts as an effective chiral proton shuttle to control the enantioselectivity.