Sex Differences in the Prevalence of Congenital Anomalies: A Population-Based Study
Sex Differences in the Prevalence of Congenital Anomalies: A Population-Based Study
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DOI：
10.1002/bdra.22846
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发表时间：
2011-10-01
影响因子：
--
通讯作者：
Rankin, Judith
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文献类型：
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作者：
Tennant, Peter W. G.;Samarasekera, S. Dilhani;Rankin, Judith
背景：关于各种先天性异常亚型性别分布的资料有限。本研究利用来自英格兰北部的高质量人口数据，调查了先天性异常患病率的性别差异，包括总体和亚型。方法：从北方先天性异常调查（NorCAS）中提取1985-2003年单胎妊娠中发生的先天性异常信息。根据欧洲先天性异常监测指南，畸形按组、亚型和综合征分类。计算了一系列先天性异常亚型的相对危险度（rr），比较了男性和女性的患病率。结果：研究期间共发现12795例符合条件的先天性异常，其中男性7019例（54.9%），女性5776例（45.1%）。总体而言，受先天性异常影响的妊娠中，男性胎儿明显多于女性胎儿（RR，男性vs女性5 1.15；95%可信区间[CI]， 1.11-1.19），但不同亚型间存在显著异质性（p < 0.001）。110种独特亚型中的44种（40%）在男性中的患病率至少比女性高40%，受影响的亚型发生在所有主要异常组中。110种独特亚型中的13种（12%）在女性中比男性中至少流行40%，但神经管缺陷的女性偏倚RR比先前报道的要低（RR = 0.84; 95% CI, 0.73-0.95）。结论：这项研究增加了越来越多的证据表明，在广泛的先天性异常亚型患病率的性别特异性差异。出生缺陷研究（A部分）91:894-901,2011。(C) 2011 Wiley-Liss, Inc。
BACKGROUND: Limited data is available concerning the sex distribution of various congenital anomaly subtypes. This study investigated sex differences in the prevalence of congenital anomalies, overall and by subtype, using high quality population-based data from the North of England. METHODS: Information on congenital anomalies occurring among singleton pregnancies during 1985-2003 were extracted from the Northern Congenital Abnormality Survey (NorCAS). Anomalies were categorized by groups, subtypes, and syndromes according to the European Surveillance of Congenital Anomalies guidelines. Relative risks (RRs) comparing the prevalences in males to that in females were calculated for a range of congenital anomaly subtypes. RESULTS: A total of 12,795 eligible cases of congenital anomaly were identified during the study period, including 7019 (54.9%) males and 5776 (45.1%) females. Overall, male fetuses were significantly more prevalent in pregnancies affected by a congenital anomaly than female fetuses (RR, male vs. female 5 1.15; 95% confidence interval [CI], 1.11-1.19), but there was significant heterogeneity between subtypes (p < 0.001). Forty-four of 110 (40%) unique subtypes were at least 40% more prevalent in males than females, with affected subtypes occurring across all major anomaly groups. Thirteen of 110 (12%) unique subtypes were at least 40% more prevalent in females than males, but the female-biased RR of a neural tube defect was less pronounced than previously reported (RR = 0.84; 95% CI, 0.73-0.95). CONCLUSION: This study adds to the growing evidence of sex-specific differences in the prevalence of a wide range of congenital anomaly subtypes. Birth Defects Research (Part A) 91: 894-901, 2011. (C) 2011 Wiley-Liss, Inc.