Interictal alterations of the trigeminal somatosensory pathway and periaqueductal gray matter in migraine
Interictal alterations of the trigeminal somatosensory pathway and periaqueductal gray matter in migraine
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DOI：
10.1097/wnr.0b013e32801776bb
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发表时间：
2007-03-05
期刊：
影响因子：
1.7
通讯作者：
Hadjikhani, Nouchine
中科院分区：
文献类型：
--
作者：
DaSilva, Alexandre F. M.;Granziera, Cristina;Hadjikhani, Nouchine
偏头痛传统上被认为是一种非进行性的、发作性的疾病，在发作之间没有大脑异常。我们使用扩散张量成像来检查有先兆偏头痛患者、无先兆偏头痛患者和匹配的健康对照者的发作间期扩散特性。偏头痛患者沿着丘脑皮质束的各向异性分数较低。此外，有先兆的偏头痛患者三叉神经丘脑腹侧束的各向异性分数较低，而无先兆的偏头痛患者中脑导水管周围灰质腹外侧的各向异性分数较低。我们的研究结果表明，存在永久性发作间期的变化，偏头痛，指向三叉神经的躯体感觉和调制疼痛系统的影响。
Migraine has been traditionally considered a nonprogressive, paroxysmal disorder with no brain abnormalities between attacks. We used diffusion tensor imaging to examine interictal diffusion properties of the brains of migraineurs with aura, migraineurs without aura and matched healthy controls. Areas of lower fractional anisotropy were present in migraineurs along the thalamocortical tract. In addition, migraineurs with aura had lower fractional anisotropy in the ventral trigeminothalamic tract, and migraineurs without aura had lower fractional anisotropy in the ventrolateral periaqueductal grey matter. Our results indicate the presence of permanent interictal changes in migraineurs, pointing to an effect of migraine on the trigeminal somatosensory and modulatory pain systems.