Cortical projections of functionally identified thalamic trigeminovascular neurons: implications for migraine headache and its associated symptoms.
Cortical projections of functionally identified thalamic trigeminovascular neurons: implications for migraine headache and its associated symptoms.
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DOI：
10.1523/jneurosci.3285-11.2011
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发表时间：
2011-10-05
期刊：
影响因子：
--
通讯作者：
Burstein R
中科院分区：
文献类型：
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作者：
Noseda R;Jakubowski M;Kainz V;Borsook D;Burstein R
这项研究确定了三叉神经血管(硬脑膜敏感)丘脑神经元在多个皮质区域的大量轴突，并提出了一个新的框架来概念化偏头痛及其相关症状。单个硬脑膜敏感神经元在一阶和高阶中继核中被识别和电生理学特征，并在细胞旁填充顺行示踪剂，标记其胞体和突起。腹后内侧核(VPM)内的一级神经元主要投射到三叉神经初级(S1)和次级(S2)躯体感觉和岛叶皮质。高级神经元位于后核(Po)、外侧后核(LP)和外侧背核(LD)，投射到三叉神经和三叉神经外的S1和S2区，以及顶叶联系、脾后皮质、听觉皮质、外胚脑皮质、运动皮质和视觉皮质。轴突乔木以不同的密度分布在不同皮质区域的大部分层中。这种丘脑皮质投射的平行网络可能在将伤害性信号从脑膜传递到皮质的过程中扮演不同的角色。单个对硬脑膜敏感的Po神经元投射到许多在功能上不同的、解剖上遥远的皮质区域，这一发现扩展了当前对高阶丘脑神经元投射模式的看法，并将它们定位为直接传递伤害性信息，而不是间接地从一个皮质区域传递到另一个皮质区域。这种对不同皮质区域的广泛输入涉及到情感、运动功能、视觉和听觉感知、空间定向、记忆提取和嗅觉的调节，这可能解释了偏头痛期间一些常见的神经功能障碍。
This study identifies massive axonal arbors of trigeminovascular (dura-sensitive) thalamic neurons in multiple cortical areas and proposes a novel framework for conceptualizing migraine headache and its associated symptoms. Individual dura-sensitive neurons identified and characterized electrophysiologically in first-order and higher-order relay thalamic nuclei were juxtacellularly filled with an anterograde tracer that labeled their cell bodies and processes. First-order neurons located in the ventral posteromedial (VPM) nucleus projected mainly to trigeminal areas of primary (S1) as well as secondary (S2) somatosensory and insular cortices. Higher-order neurons located in the posterior (Po), lateral posterior (LP) and lateral dorsal (LD) nuclei projected to trigeminal and extratrigeminal areas of S1 and S2, as well as parietal association, retrosplenial, auditory, ectorhinal, motor and visual cortices. Axonal arbors spread at various densities across most layers of the different cortical areas. Such parallel network of thalamocortical projections may play different roles in the transmission of nociceptive signals from the meninges to the cortex. The findings that individual dura-sensitive Po neurons project to many functionally-distinct and anatomically-remote cortical areas extend current thinking on projection patterns of high-order thalamic neurons and position them to relay nociceptive information directly, rather than indirectly from one cortical area to another. Such extensive input to diverse cortical areas that are involved in regulation of affect, motor function, visual and auditory perception, spatial orientation, memory retrieval, and olfaction may explain some of the common disturbances in neurological functions during migraine.