Successful treatment of life-threatening intestinal ulcer in Behcet's disease with infliximab: rapid healing of Behcet's ulcer with infliximab
Successful treatment of life-threatening intestinal ulcer in Behcet's disease with infliximab: rapid healing of Behcet's ulcer with infliximab
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DOI：
10.1007/s10067-006-0410-3
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发表时间：
2007-08-01
影响因子：
3.4
通讯作者：
Park, Sung-Hwan
中科院分区：
文献类型：
--
作者：
Ju, Ji Hyeon;Kwok, Seung-Ki;Park, Sung-Hwan
白塞氏病是一种慢性、复发性、多系统炎症性疾病，主要特征为复发性口腔生殖器溃疡、皮肤受累和葡萄膜炎。轻度病例中，复发性粘膜皮肤病变可能是唯一的症状，但严重病例中可能会出现眼部、胃肠道和中枢神经系统受累。我们在这项研究中报告了使用英夫利昔单抗成功治疗白塞氏病患者回肠溃疡引起的严重危及生命的胃肠道出血的情况。抗肿瘤坏死因子（TNF）治疗可能是白塞氏病大出血患者和不稳定患者或其他 TNF-α 介导的自身免疫性疾病急性出血患者的紧急治疗选择。抗 TNF 治疗的另一种选择可能是作为保守治疗和手术治疗之间的桥梁治疗。
Behcet's disease is a chronic, relapsing, multisystem inflammatory disorder characterized predominantly by recurrent orogenital ulcers, skin involvement, and uveitis. Recurrent mucocutaneous lesions may be the only symptom in mild cases, but ocular, gastrointestinal, and central nervous system involvement may occur in severe cases. We report in this study the successful treatment with infliximab of severe life-threatening GI bleeding caused by an ileal ulcer in a patient with Behcet's disease. Antitumor necrosis factor (TNF) therapy could be an emergency therapeutic option in patients with massively bleeding Behcet's disease and unstable patients or those with acute bleeding with other TNF-alpha-mediated autoimmune diseases. Another option for anti-TNF therapy could be as bridging management between conservative and surgical treatment.