Diabetic cataract and the total antioxidant status in aqueous humor
Diabetic cataract and the total antioxidant status in aqueous humor
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DOI：
10.1515/cclm.2001.024
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发表时间：
2001-02-01
影响因子：
6.8
通讯作者：
Akçay, F
中科院分区：
文献类型：
--
作者：
Aksoy, H;Keles, S;Akçay, F
已经提出了糖尿病白内障形成的一些机制，例如组织山梨醇浓度过高、晶状体蛋白糖基化异常以及眼内区域自由基产生增加。我们测量了患有白内障的糖尿病患者 (n=20) 和非糖尿病患者 (n=16) 的房水中的总抗氧化状态和尿酸水平。糖尿病合并白内障患者的房水总抗氧化状态显着低于老年性白内障患者（p = 0.001）。与老年性白内障组相比，糖尿病性白内障组的血清和房水尿酸水平显着降低。在糖尿病性白内障组中，房水抗氧化状态与房水尿酸水平呈正相关（p < 0.05）。这项研究的结果表明，糖尿病性白内障患者房水抗氧化状态降低可能与房水尿酸降低有关。房水尿酸水平的降低可能导致白内障形成的加速。
Some mechanisms have been proposed for cataract formation in diabetes mellitus such as excessive tissue sorbitol concentrations, abnormal glycosylation of lens proteins and increased free radical production in the intraocular region. We measured total antioxidant status and uric acid levels in aqueous humor from diabetic (n=20) and non-diabetic subjects (n=16) with cataracts. The patients with diabetes and cataract had significantly lower aqueous humor total antioxidant status than those with senile cataract (p = 0.001). Serum and aqueous humor uric acid levels were significantly lower in the diabetic cataract group compared to the senile cataract group. In the diabetic cataract group, the aqueous humor antioxidant status correlated positively with the aqueous humor uric acid levels (p < 0.05). The results of this study suggest that reduced aqueous humor antioxidant status might be associated with reduced aqueous humor uric acid in patients with diabetic cataract. This decrease in aqueous humor uric acid levels might lead to the acceleration of cataract formation.