Dynamics of Reactive Oxygen Metabolites and Biological Antioxidant Potential in the Acute Stage of Kawasaki Disease
Dynamics of Reactive Oxygen Metabolites and Biological Antioxidant Potential in the Acute Stage of Kawasaki Disease
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DOI：
10.1253/circj.cj-10-0605
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发表时间：
2011-10-01
影响因子：
3.3
通讯作者：
Hamaoka, Kenji
中科院分区：
文献类型：
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作者：
Yahata, Tomoyo;Suzuki, Chinatsu;Hamaoka, Kenji
背景：为了解川崎病(KD)急性期患者氧化还原调节系统活性的动态变化，探讨川崎病(KD)血管损伤和重塑的机制。方法与结果：对19例KD患者进行了ROM、BAP、高敏C反应蛋白(hs-CRP)、白介素1、2、6和肿瘤坏死因子-a的检测。静脉注射免疫球蛋白(IVIG)后2周，ROM仅与hs-CRP显著相关(P<；0.05)。将患者进一步分为对IVIG反应良好(A组)或反应差(B组)。两组ROM值均显著高于对照组(P<；0.01)。A组在IVIG治疗后即刻和2周ROM均下降(P
Background: The dynamics of oxidation/reduction control system activities using reactive oxygen metabolites (ROM) and biological antioxidant potential (BAP) in acute stage patients was evaulated to understand the mechanism of vascular injury and remodeling in Kawasaki disease (KD).Methods and Results: ROM, BAP, high-sensitivity C-reactive protein (hs-CRP), interleukin-1,2,6, and tumour necrosis factor-a in 19 KD patients were measured. ROM decreased in good correlation only with hs-CRP (P < 0.05) at 2 weeks after intravenous immunoglobulin (IVIG). Patients were further classified as responding well (Group A) or responding poorly (Group B) to IVIG. Both treatment groups had significantly higher ROM values than the control group (P < 0.01). ROM decreased in Group A both immediately and 2 weeks after the IVIG treatment (P