Lotus seed oligosaccharides at various dosages with prebiotic activity regulate gut microbiota and relieve constipation in mice
Lotus seed oligosaccharides at various dosages with prebiotic activity regulate gut microbiota and relieve constipation in mice
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具有益生元活性的不同剂量莲子寡糖调节肠道微生物群并缓解小鼠便秘
DOI：
10.1016/j.fct.2019.110838
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发表时间：
2019-12-01
影响因子：
4.3
通讯作者：
Lu, Xu
中科院分区：
文献类型：
--
作者：
Su, Han;Chen, Jinghao;Lu, Xu
本研究的目的是评价莲子低聚糖（由LSO 2、LSO 3 -1、LSO 3 -2和LSO 4组成的制剂;相对比例为1.107：0.554：0.183：0.443，m/m/m/m）在0.42、0.83 g/d/kg bw和2.49 g/d/kg bw剂量下对小鼠肠道微生物群组成和肠内容物推进的影响。结果显示，处理组小鼠的粪便含水量增加;肠道微生物群多样性低于其他组;小鼠盲肠中存在大量动物群。同时，低聚糖能增加肠道内短链脂肪酸（SCFA）细菌的数量;低聚糖还能增加肠道内SCFA的浓度，从而增加小鼠血清中细胞因子的浓度。综上所述，这些发现表明LOS或与抗性淀粉组合具有更好的缓解便秘的效果。
The aim of this study was to evaluate the effects of lotus seed oligosaccharides (formulation consisting of LSO2, LSO3-1, LSO3-2 and LSO4; relative ratios are 1.107:0.554:0.183:0.443, m/m/m/m) at dosages of 0.42, 0.83 g/d/kg bw and 2.49 g/d/kg bw on the microbiota composition and the propulsion of intestinal contents in the gut of mice. The results showed that fecal water content increased in treated mice; there was less gut microbiota diversity than in other groups; and there was a large number of fauna in the cecum of the mice. At the same time, the number of short-chain fatty acid (SCFA) bacterial producers increased after feeding with oligosaccharides; Lotus seed oligosaccharides (LOS) also enhanced the concentration of SCFAs in the intestine, which also increased the concentration of cytokines in the serum of mice. In conclusion, these findings suggest that LOS or combination with resistant starch has a better effect on relieving constipation.