RENAL nephrometry score is a predictive factor for the annual growth rate of renal mass
RENAL nephrometry score is a predictive factor for the annual growth rate of renal mass
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DOI：
10.1111/iju.12388
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发表时间：
2014-06-01
影响因子：
2.6
通讯作者：
Nonomura, Katsuya
中科院分区：
文献类型：
--
作者：
Matsumoto, Ryuji;Abe, Takashige;Nonomura, Katsuya
目的：评价肾功能评分与肾肿瘤年增长率的关系。方法：本研究对47例肾肿瘤患者进行了至少12个月的随访，其中26例经病理证实为肾细胞癌。根据计算机断层扫描上肿瘤最大直径的变化计算肿瘤的年生长率，并由两名资深泌尿科医生在初始成像时记录肾功能评分。用线性回归模型分析包括肾功能评分在内的临床特征与年增长率之间的关系。结果：确诊时肿瘤的中位大小为1.7 cm(0.6-5.8)。诊断时肾功能评分中位数为7(范围4-10)。总体而言，肿瘤生长速度的中位数为每年0.34厘米(范围-0.19-2.0)。线性回归分析显示，肿瘤的年生长率与肾功能评分有关(P<；0.0001)，但与确诊时的年龄、性别和初始肿瘤大小无关。此外，在26例经病理证实的肾癌患者中，肾功能评分与年生长率的相关性仍然显著。结论：肾功能评分与肾肿块的年增长率相关。我们的研究结果进一步支持了肾功能评分与肿瘤生物学之间的联系。
Objective: To evaluate the association between the RENAL nephrometry score and annual growth rates of renal masses presumed to be renal cell carcinoma.Methods: The current study included 47 renal tumors followed up for at least 12 months, of which 26 tumors were found to be pathologically proven renal cell carcinomas. Annual tumor growth rates were calculated from changes in the maximal diameter on computed tomography, and RENAL nephrometry scores were recorded on initial imaging by two senior urologists. The associations between clinical characteristics including the RENAL nephrometry score and annual growth rates were analyzed using a linear regression model.Results: The median tumor size at diagnosis was 1.7cm (range 0.6-5.8). The median nephrometry score at diagnosis was 7 (range 4-10). Overall, the median tumor growth rate was 0.34 cm per year (range -0.19-2.0). Linear regression analysis showed that the annual tumor growth rate was associated with the RENAL nephrometry score (P < 0.0001), but it was independent of the age at diagnosis, sex and initial tumor size. In addition, the correlation between the RENAL nephrometry score and annual growth rate remained significant in the 26 pathologically proven renal cell carcinomas.Conclusions: The RENAL nephrometry score is associated with the annual growth rate of renal masses. Our findings further support the association between the RENAL nephrometry score and tumor biology.