The effect of di- and trivalent iron on the intestinal absorption of aluminum in rats

The effect of di- and trivalent iron on the intestinal absorption of aluminum in rats
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DOI:
10.1016/0041-008x(87)90326-7
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发表时间:
1987-09
影响因子:
3.8
通讯作者:
G. Voet;F. Wolff
G. Voet;F. Wolff
中科院分区:
医学3区
文献类型:
--
作者:
G. Voet;F. Wolff

文献摘要

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采用大鼠小肠原位灌流系统,结合体循环和门静脉采血,研究了铁(Fe)对铝(Al)在小肠吸收的影响。用含有0.0、10.0、15.0、20.0和25.0 mmol/L氯化铝和5 mmol/L Fe(II)或Fe(III)氯化物的培养基(pH 3.0)灌注肠道。无论是管腔消失,也不肠吸收铝的影响由Fe(III)。然而,Fe(II)增强了管腔消失,减少了Al的吸收。
The effect of iron (Fe) on the intestinal absorption of aluminum (Al) was studied in an in situ perfusion system of rat small intestine in combination with systemic and portal blood sampling. The gut was perfused with media containing 0.0, 10.0, 15.0, 20.0, and 25.0 mmol/liter Al chloride and 5 mmol/liter Fe(II) or Fe(III) chloride at pH 3.0. Neither luminal disappearance nor intestinal absorption of Al were affected by Fe(III). Fe(II), however, enhanced luminal disappearance and reduced absorption of Al.