Recent advances in coarse-grained modeling of virus assembly.
Recent advances in coarse-grained modeling of virus assembly.
复制标题
病毒组装粗粒度建模的最新进展。
DOI：
10.1016/j.coviro.2016.02.012
复制
发表时间：
2016-06
影响因子：
5.9
通讯作者：
Zandi R
中科院分区：
文献类型：
--
作者：
Hagan MF;Zandi R
在许多病毒家族中，在包装基因组核酸时，数以万计的蛋白质自发组装成衣壳(蛋白质壳)。本文综述了这些动力学过程的计算建模的最新进展。我们概述了最近的技术和算法发展，这些发展使模拟能够描述与组装相关的大范围的长度和时间尺度，在与实验更接近的条件下，比以前的工作更接近实验。然后，我们描述了两个例子，在这些例子中，计算建模最近提供了对实验的重要补充。
In many virus families, tens to thousands of proteins assemble spontaneously into a capsid (protein shell) while packaging the genomic nucleic acid. This review summarizes recent advances in computational modeling of these dynamical processes. We present an overview of recent technological and algorithmic developments, which are enabling simulations to describe the large ranges of length-and time-scales relevant to assembly, under conditions more closely matched to experiments than in earlier work. We then describe two examples in which computational modeling has recently provided an important complement to experiments.