SMALL AIRWAYS DISEASE ASSOCIATED WITH MINERAL DUST EXPOSURE
SMALL AIRWAYS DISEASE ASSOCIATED WITH MINERAL DUST EXPOSURE
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DOI：
10.1055/s-2007-1006266
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发表时间：
1992-03-01
期刊：
影响因子：
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通讯作者：
CHURG, A
中科院分区：
文献类型：
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作者：
CHURG, A
与吸入无机矿物粉尘相关的典型病变是间质纤维化，可为弥漫性纤维化，如石棉肺，或结节性纤维化，如单纯性矽肺。同样，与矿物粉尘接触有关的典型功能变化是一种限制性缺陷。然而，最近对人类的形态学研究以及对动物的实验研究表明，矿物粉尘也会对小气道造成损害。与此同时，越来越多的人认识到，在某些情况下，矿物粉尘暴露与气流阻塞而不是气流限制有关。在本文中，我将简要回顾在暴露于粉尘的人类和动物的气道中所见的形态学发现，考虑这些病变的可能发病机制，并讨论这些变化在何处可能符合粉尘引起的气流阻塞的概念。
The lesion classically associated with the inhalation of inorganic mineral dusts is interstitial fibrosis, either diffuse, for example in asbestosis, or nodular, for example in simple silicosis. Similarly, the classic functional change associated with mineral dust exposure is a restrictive deficit. However, recent morphologic studies in man as well as experimental studies in animals have shown that mineral dusts also produce lesions in the small airways. At the same time, there has been a growing recognition that mineral dust exposure in some instances is associated with airflow obstruction rather than restriction. In this article I shall briefly review the morphologic findings seen in the airways in dustexposed humans and animals, consider the possible pathogenesis of these lesions, and discuss where such changes may fit into the concept of dust-induced airflow obstruction.