Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease
Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease
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DOI：
10.1212/01.wnl.0000271883.45010.8a
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发表时间：
2007-10-23
期刊：
影响因子：
9.9
通讯作者：
Ascherio, Alberto
中科院分区：
文献类型：
--
作者：
Simon, Kelly Claire;Chen, Honglei;Ascherio, Alberto
目的：确定高血压、高胆固醇血症或糖尿病史是否与帕金森病（PD）的风险相关。方法：在两个大队列的参与者中进行前瞻性研究：护士健康研究（121，046名女性）和健康专业人员随访研究（50，833名男性）。基线时年龄为30 - 55岁的女性平均随访时间为22.9年，基线时年龄为40 - 75岁的男性平均随访时间为12.6年。PD的相对危险度（RR）由调整潜在混杂因素的考克斯比例风险模型估计。在调整年龄和吸烟（包年）后，PD风险与自我报告的高血压（RR = 0.96，95%CI = 0.80至1.15）、高胆固醇（RR = 0.98，95%CI = 0.82至1.19）或糖尿病（RR = 1.04，95%CI = 0.74至1.46）病史无关。PD风险随着自我报告的总胆固醇水平的增加而适度降低（总胆固醇升高50 mg/ dL的RR = 0.86，95% CI = 0.78 - 0.95，趋势p = 0.02），但使用降胆固醇药物与PD风险无关（使用者与非使用者比较的RR = 0.85，95% CI = 0.59至1.23）。在个人与PD，收缩压是类似的noncases的诊断时间，但下降aftersee.Conclusions：这个大型前瞻性研究的结果表明，帕金森病的风险是没有显着相关的高血压，高胆固醇血症，或糖尿病的历史，但可能会适度下降，随着血胆固醇水平的增加。
Objective: To determine whether history of hypertension, hypercholesterolemia, or diabetes is associated with risk of Parkinson disease ( PD).Methods: Prospective study among participants in two large cohorts: the Nurses' Health Study ( 121,046 women) and the Health Professionals Follow- up Study ( 50,833 men). Mean duration of follow- up was 22.9 years in women, aged 30 to 55 years at baseline, and 12.6 years in men, aged 40 to 75 years at baseline. Relative risks ( RRs) of PD were estimated from a Cox proportional hazards model adjusting for potential confounders.Results: We identified a total of 530 incident cases of PD during the follow- up. Risk of PD was not associated with self- reported history of hypertension ( RR = 0.96, 95% CI = 0.80 to 1.15), high cholesterol ( RR = 0.98, 95% CI = 0.82 to 1.19), or diabetes ( RR = 1.04, 95% CI = 0.74 to 1.46), after adjusting for age and smoking in pack- years. Risk of PD decreased modestly with increasing levels of self- reported total cholesterol ( RR for a 50- mg/ dL increase in total cholesterol = 0.86, 95% CI = 0.78 to 0.95, p for trend = 0.02), but use of cholesterol- lowering drugs was not associated with PD risk ( RR comparing users with nonusers = 0.85, 95% CI = 0.59 to 1.23). Among individuals with PD, systolic blood pressure was similar to noncases up to the time of diagnosis but declined afterward.Conclusions: Results of this large prospective study suggest that Parkinson disease risk is not significantly related to history of hypertension, hypercholesterolemia, or diabetes but may modestly decline with increasing blood cholesterol levels.